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Post-lockdown abatement of COVID-19 by fast periodic switching.
Bin, Michelangelo; Cheung, Peter Y K; Crisostomi, Emanuele; Ferraro, Pietro; Lhachemi, Hugo; Murray-Smith, Roderick; Myant, Connor; Parisini, Thomas; Shorten, Robert; Stein, Sebastian; Stone, Lewi.
  • Bin M; Department of Electrical and Electronic Engineering, Imperial College London, London, United Kingdom.
  • Cheung PYK; Dyson School of Design Engineering, Imperial College London, London, United Kingdom.
  • Crisostomi E; Department of Energy, Systems, Territory and Constructions Engineering, University of Pisa, Pisa, Italy.
  • Ferraro P; Dyson School of Design Engineering, Imperial College London, London, United Kingdom.
  • Lhachemi H; L2S, CentraleSupélec, Gif-sur-Yvette, France.
  • Murray-Smith R; School of Computing Science, University of Glasgow, Glasgow, Scotland.
  • Myant C; Dyson School of Design Engineering, Imperial College London, London, United Kingdom.
  • Parisini T; Department of Electrical and Electronic Engineering, Imperial College London, London, United Kingdom.
  • Shorten R; Department of Engineering and Architecture, University of Trieste, Trieste, Italy.
  • Stein S; KIOS Research and Innovation Center of Excellence, University of Cyprus, Nicosia, Cyprus.
  • Stone L; Dyson School of Design Engineering, Imperial College London, London, United Kingdom.
PLoS Comput Biol ; 17(1): e1008604, 2021 01.
Article in English | MEDLINE | ID: covidwho-1040038
ABSTRACT
COVID-19 abatement strategies have risks and uncertainties which could lead to repeating waves of infection. We show-as proof of concept grounded on rigorous mathematical evidence-that periodic, high-frequency alternation of into, and out-of, lockdown effectively mitigates second-wave effects, while allowing continued, albeit reduced, economic activity. Periodicity confers (i) predictability, which is essential for economic sustainability, and (ii) robustness, since lockdown periods are not activated by uncertain measurements over short time scales. In turn-while not eliminating the virus-this fast switching policy is sustainable over time, and it mitigates the infection until a vaccine or treatment becomes available, while alleviating the social costs associated with long lockdowns. Typically, the policy might be in the form of 1-day of work followed by 6-days of lockdown every week (or perhaps 2 days working, 5 days off) and it can be modified at a slow-rate based on measurements filtered over longer time scales. Our results highlight the potential efficacy of high frequency switching interventions in post lockdown mitigation. All code is available on Github at https//github.com/V4p1d/FPSP_Covid19. A software tool has also been developed so that interested parties can explore the proof-of-concept system.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Communicable Disease Control / Models, Statistical / COVID-19 Type of study: Observational study / Prognostic study Topics: Vaccines Limits: Humans Language: English Journal: PLoS Comput Biol Journal subject: Biology / Medical Informatics Year: 2021 Document Type: Article Affiliation country: Journal.pcbi.1008604

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Communicable Disease Control / Models, Statistical / COVID-19 Type of study: Observational study / Prognostic study Topics: Vaccines Limits: Humans Language: English Journal: PLoS Comput Biol Journal subject: Biology / Medical Informatics Year: 2021 Document Type: Article Affiliation country: Journal.pcbi.1008604