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Digestive manifestations in COVID-19: Prevalence and prognostic impact.
Tunis Med ; 98(8-9): 643-650, 2020.
Article in English | MEDLINE | ID: covidwho-1040341
ABSTRACT

BACKGROUND:

Since its declaration in december 2019, a novel coronavirus, the SARS-CoV-2 was rapidly responsible for a major pandemic. COVID-19 is mainly manifested by respiratory symptoms,however, digestive manifestations have been reported, raising the hypothesis of the viral digestive tropism.

AIMS:

Specify the digestive manifestations due to the SARS-CoV-2, and their impact on the disease prognosis and describe the COVID-19 effect in patients with underlying digestive disease.

METHODS:

Ageneral review of the medical literature was conducted via Medline® database, through various combinations of the following keywordsSARS-CoV-2, COVID-19, gastrointestinal tract, digestive system, inflammatory bowel diseases, liver, liver injury, chronic liver disease, neoplasms. The most relevant articles were selected.

RESULTS:

The SARS-CoV-2 tropism for the digestive tract has been confirmed by the identification of the enterocyte as a target cell of the virus. Viral particles and RNA detection in stool of infected patients has raised the potential for feco-oral transmission of the virus. Gastrointestinal manifestations were frequent and may even be revealing or isolated. Diarrhea was the most characteristic symptom. Frequent liver involvement is associated with a more severe form of the disease. Patients with digestive cancer and chronic liver disease are at risk for a severe form of SARS-CoV-2 infection.

CONCLUSION:

The clinician is required to know this type of manifestations in order to limit the delay in diagnosis and to better assess the prognosis.
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Collection: International databases Database: MEDLINE Main subject: Gastrointestinal Diseases / COVID-19 Type of study: Experimental Studies / Observational study / Prognostic study / Reviews Topics: Long Covid Limits: Humans Language: English Journal: Tunis Med Year: 2020 Document Type: Article

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Collection: International databases Database: MEDLINE Main subject: Gastrointestinal Diseases / COVID-19 Type of study: Experimental Studies / Observational study / Prognostic study / Reviews Topics: Long Covid Limits: Humans Language: English Journal: Tunis Med Year: 2020 Document Type: Article