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mRNA-Enhanced Cell Therapy and Cardiovascular Regeneration.
Chanda, Palas K; Sukhovershin, Roman; Cooke, John P.
  • Chanda PK; RNA Therapeutics Program, Center for Cardiovascular Regeneration, Department of Cardiovascular Sciences, Houston Methodist Research Institute, 6670 Bertner Ave., Houston, TX 77030, USA.
  • Sukhovershin R; RNA Therapeutics Program, Center for Cardiovascular Regeneration, Department of Cardiovascular Sciences, Houston Methodist Research Institute, 6670 Bertner Ave., Houston, TX 77030, USA.
  • Cooke JP; RNA Therapeutics Program, Center for Cardiovascular Regeneration, Department of Cardiovascular Sciences, Houston Methodist Research Institute, 6670 Bertner Ave., Houston, TX 77030, USA.
Cells ; 10(1)2021 Jan 19.
Article in English | MEDLINE | ID: covidwho-1041449
ABSTRACT
mRNA has emerged as an important biomolecule in the global call for the development of therapies during the COVID-19 pandemic. Synthetic in vitro-transcribed (IVT) mRNA can be engineered to mimic naturally occurring mRNA and can be used as a tool to target "undruggable" diseases. Recent advancement in the field of RNA therapeutics have addressed the challenges inherent to this drug molecule and this approach is now being applied to several therapeutic modalities, from cancer immunotherapy to vaccine development. In this review, we discussed the use of mRNA for stem cell generation or enhancement for the purpose of cardiovascular regeneration.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Regeneration / RNA, Messenger / Cardiovascular Diseases / Cell- and Tissue-Based Therapy Topics: Vaccines Limits: Humans Language: English Year: 2021 Document Type: Article Affiliation country: Cells10010187

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Regeneration / RNA, Messenger / Cardiovascular Diseases / Cell- and Tissue-Based Therapy Topics: Vaccines Limits: Humans Language: English Year: 2021 Document Type: Article Affiliation country: Cells10010187