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Cupric Oxide Coating That Rapidly Reduces Infection by SARS-CoV-2 via Solids.
Hosseini, Mohsen; Chin, Alex W H; Behzadinasab, Saeed; Poon, Leo L M; Ducker, William A.
  • Hosseini M; Dept. of Chemical Engineering and Center for Soft Matter and Biological Physics, Virginia Tech, Blacksburg Virginia 24061, United States.
  • Chin AWH; School of Public Health, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong Special Administrative Region, Hong Kong, China.
  • Behzadinasab S; Dept. of Chemical Engineering and Center for Soft Matter and Biological Physics, Virginia Tech, Blacksburg Virginia 24061, United States.
  • Poon LLM; School of Public Health, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong Special Administrative Region, Hong Kong, China.
  • Ducker WA; HKU-Pasteur Research Pole, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong, China.
ACS Appl Mater Interfaces ; 13(5): 5919-5928, 2021 Feb 10.
Article in English | MEDLINE | ID: covidwho-1042382
ABSTRACT
The ongoing COVID-19 pandemic has created a need for coatings that reduce infection from SARS-CoV-2 via surfaces. Such a coating could be used on common touch surfaces (e.g., door handles and railings) to reduce both disease transmission and fear of touching objects. Herein, we describe the design, fabrication, and testing of a cupric oxide anti-SARS-CoV-2 coating. Rapid loss of infectivity is an important design criterion, so a porous hydrophilic coating was created to allow rapid infiltration of aqueous solutions into the coating where diffusion distances to the cupric oxide surface are short and the surface area is large. The coating was deposited onto glass from a dispersion of cuprous oxide in ethanol and then thermally treated at 700 °C for 2 h to produce a CuO coating that is ≈30 µm thick. The heat treatment oxidized the cuprous oxide to cupric oxide and sintered the particles into a robust film. The SARS-CoV-2 infectivity from the CuO film was reduced by 99.8% in 30 min and 99.9% in 1 h compared to that from glass. The coating remained hydrophilic for at least 5 months, and there was no significant change in the cross-hatch test of robustness after exposure to 70% ethanol or 3 wt % bleach.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Copper / SARS-CoV-2 / COVID-19 Type of study: Randomized controlled trials Limits: Animals / Humans Language: English Journal: ACS Appl Mater Interfaces Journal subject: Biotechnology / Biomedical Engineering Year: 2021 Document Type: Article Affiliation country: Acsami.0c19465

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Copper / SARS-CoV-2 / COVID-19 Type of study: Randomized controlled trials Limits: Animals / Humans Language: English Journal: ACS Appl Mater Interfaces Journal subject: Biotechnology / Biomedical Engineering Year: 2021 Document Type: Article Affiliation country: Acsami.0c19465