Your browser doesn't support javascript.
Proteinuria in COVID-19: prevalence, characterization and prognostic role.
Huart, Justine; Bouquegneau, Antoine; Lutteri, Laurence; Erpicum, Pauline; Grosch, Stéphanie; Résimont, Guillaume; Wiesen, Patricia; Bovy, Christophe; Krzesinski, Jean-Marie; Thys, Marie; Lambermont, Bernard; Misset, Benoît; Pottel, Hans; Mariat, Christophe; Cavalier, Etienne; Burtey, Stéphane; Jouret, François; Delanaye, Pierre.
  • Huart J; Department of Nephrology-Dialysis-Transplantation, Service de Dialyse, CHU Sart Tilman, University of Liège (CHU ULiege), 4000, Liège, Belgium.
  • Bouquegneau A; Groupe Interdisciplinaire de Géno-protéomique Appliquée, Cardiovascular Sciences, University of Liège, Liège, Belgium.
  • Lutteri L; Department of Nephrology-Dialysis-Transplantation, Service de Dialyse, CHU Sart Tilman, University of Liège (CHU ULiege), 4000, Liège, Belgium.
  • Erpicum P; Department of Clinical Chemistry, CHU Sart Tilman, University of Liège (CHU ULiege), Liège, Belgium.
  • Grosch S; Department of Nephrology-Dialysis-Transplantation, Service de Dialyse, CHU Sart Tilman, University of Liège (CHU ULiege), 4000, Liège, Belgium.
  • Résimont G; Groupe Interdisciplinaire de Géno-protéomique Appliquée, Cardiovascular Sciences, University of Liège, Liège, Belgium.
  • Wiesen P; Department of Nephrology-Dialysis-Transplantation, Service de Dialyse, CHU Sart Tilman, University of Liège (CHU ULiege), 4000, Liège, Belgium.
  • Bovy C; Department of Nephrology-Dialysis-Transplantation, Service de Dialyse, CHU Sart Tilman, University of Liège (CHU ULiege), 4000, Liège, Belgium.
  • Krzesinski JM; Department of Intensive Care, CHU Sart Tilman, University of Liège (CHU ULiege), Liège, Belgium.
  • Thys M; Department of Nephrology-Dialysis-Transplantation, Service de Dialyse, CHU Sart Tilman, University of Liège (CHU ULiege), 4000, Liège, Belgium.
  • Lambermont B; Department of Nephrology-Dialysis-Transplantation, Service de Dialyse, CHU Sart Tilman, University of Liège (CHU ULiege), 4000, Liège, Belgium.
  • Misset B; Groupe Interdisciplinaire de Géno-protéomique Appliquée, Cardiovascular Sciences, University of Liège, Liège, Belgium.
  • Pottel H; Department of Medico-Economic Information, CHU Sart Tilman, University of Liège (CHU ULiege), Liège, Belgium.
  • Mariat C; Department of Intensive Care, CHU Sart Tilman, University of Liège (CHU ULiege), Liège, Belgium.
  • Cavalier E; Department of Intensive Care, CHU Sart Tilman, University of Liège (CHU ULiege), Liège, Belgium.
  • Burtey S; Department of Public Health and Primary Care, KU Leuven Campus Kulak Kortrijk, Kortrijk, Belgium.
  • Jouret F; Nephrology, Dialysis and Renal Transplantation Department, Hôpital Nord, CHU de Saint-Etienne, Jean Monnet University, COMUE Université de Lyon, Lyon, France.
  • Delanaye P; Department of Clinical Chemistry, CHU Sart Tilman, University of Liège (CHU ULiege), Liège, Belgium.
J Nephrol ; 34(2): 355-364, 2021 04.
Article in English | MEDLINE | ID: covidwho-1042399
ABSTRACT

BACKGROUND:

Proteinuria has been commonly reported in patients with COVID-19. However, only dipstick tests have been frequently used thus far. Here, the quantification and characterization of proteinuria were investigated and their association with mortality was assessed.

METHODS:

This retrospective, observational, single center study included 153 patients, hospitalized with COVID-19 between March 28th and April 30th, 2020, in whom total proteinuria and urinary α1-microglobulin (a marker of tubular injury) were measured. Association with mortality was evaluated, with a follow-up until May 7th, 2020.

RESULTS:

According to the Kidney Disease Improving Global Outcomes staging, 14% (n = 21) of the patients had category 1 proteinuria (< 150 mg/g of urine creatinine), 42% (n = 64) had category 2 (between 150 and 500 mg/g) and 44% (n = 68) had category 3 proteinuria (over 500 mg/g). Urine α1-microglobulin concentration was higher than 15 mg/g in 89% of patients. After a median follow-up of 27 [14;30] days, the mortality rate reached 18%. Total proteinuria and urinary α1-microglobulin were associated with mortality in unadjusted and adjusted models. This association was stronger in subgroups of patients with normal renal function and without a urinary catheter.

CONCLUSIONS:

Proteinuria is frequent in patients with COVID-19. Its characterization suggests a tubular origin, with increased urinary α1-microglobulin. Tubular proteinuria was associated with mortality in COVID-19 in our restropective, observational study.
Subject(s)
Keywords

Full text: Available Collection: International databases Database: MEDLINE Main subject: Proteinuria / COVID-19 Type of study: Cohort study / Experimental Studies / Observational study / Prognostic study Topics: Long Covid Limits: Aged / Female / Humans / Male / Middle aged Country/Region as subject: Europa Language: English Journal: J Nephrol Journal subject: Nephrology Year: 2021 Document Type: Article Affiliation country: S40620-020-00931-w

Similar

MEDLINE

...
LILACS

LIS


Full text: Available Collection: International databases Database: MEDLINE Main subject: Proteinuria / COVID-19 Type of study: Cohort study / Experimental Studies / Observational study / Prognostic study Topics: Long Covid Limits: Aged / Female / Humans / Male / Middle aged Country/Region as subject: Europa Language: English Journal: J Nephrol Journal subject: Nephrology Year: 2021 Document Type: Article Affiliation country: S40620-020-00931-w