High expression of ACE2 and TMPRSS2 and clinical characteristics of COVID-19 in colorectal cancer patients.
NPJ Precis Oncol
; 5(1): 1, 2021 Jan 21.
Article
in English
| MEDLINE | ID: covidwho-1042956
ABSTRACT
Little is known of the patterns of expression of ACE2 and TMPRSS2 or the clinical characteristics of COVID-19 in patients with COVID-19 and colorectal cancer. We found in both bulk and single-cell RNA-seq profiles that ACE2 and TMPRSS2 were expressed at high levels on tumor and normal colorectal epithelial tissues. Clinically, patients with colorectal cancer and COVID-19 were more likely to have lymphopenia, higher respiratory rate, and high hypersensitive C-reactive protein levels than matched patients with COVID-19 but without cancer. These results suggest that patients with colorectal cancer may be particularly susceptible to SARS-CoV-2 infection. Further mechanistic studies are needed to support our findings.
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Type of study:
Prognostic study
Language:
English
Journal:
NPJ Precis Oncol
Year:
2021
Document Type:
Article
Affiliation country:
S41698-020-00139-y
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