The big challenge of SARS-CoV-2 latency: testes as reservoir
63231-63-0 cell lines gene expression human diseases genomics infections physiopathology proteomics receptors Rna testes viral diseases man RNA viruses Homo Hominidae primates mammals vertebrates Chordata animals eukaryotes viruses Severe acute respiratory syndrome coronavirus 2 coronavirus disease pathophysiology ribonucleic acid testicles viral infections
; 2020(Gaceta Medica de Mexico)
Article
in Using Smart Source Parsing 35 ref
| GIM | ID: covidwho-1042995
ABSTRACT
In the efforts to explain COVID-19 pathophysiology, studies are being carried out on the correspondence between the expression of SARS-CoV-2 cell receptors and viral sequences. ACE2, CD147 and TMPRSS2 receptors expression could indicate poorly explored potential infection targets. For the genomic analysis of SARS-CoV-2 receptors, using BioGPS information was decided, which is a portal that centralizes genetic annotation resources, in combination with that of The Human Protein Atlas, the largest portal of human transcriptome and proteome data. We also reviewed the most recent articles on the subject. RNA and viral receptor proteins expression was observed in numerous anatomical sites, which partially coincides with the information reported in the literature. High expression in testicular cells markedly stood out, and it would be therefore important ruling out whether this anatomical site is a SARS-CoV-2 reservoir;otherwise, germ cell damage, as it is observed in infections with other RNA viruses, should be determined.
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Using smart source parsing 35 ref
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63231-63-0 cell lines gene expression human diseases genomics infections physiopathology proteomics receptors Rna testes viral diseases man RNA viruses Homo Hominidae primates mammals vertebrates Chordata animals eukaryotes viruses Severe acute respiratory syndrome coronavirus 2 coronavirus disease pathophysiology ribonucleic acid testicles viral infections
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Article
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