Clocks, Viruses, and Immunity: Lessons for the COVID-19 Pandemic.
J Biol Rhythms
; 36(1): 23-34, 2021 02.
Article
in English
| MEDLINE | ID: covidwho-1044068
ABSTRACT
Circadian rhythms are evolutionarily conserved anticipatory systems that allow the host to prepare and respond to threats in its environment. This article summarizes a European Biological Rhythms Society (EBRS) workshop held in July 2020 to review current knowledge of the interplay between the circadian clock and viral infections to inform therapeutic strategies against SARS-CoV-2 and COVID-19. A large body of work supports the role of the circadian clock in regulating various aspects of viral replication, host responses, and associated pathogenesis. We review the evidence describing the multifaceted role of the circadian clock, spanning host susceptibility, antiviral mechanisms, and host resilience. Finally, we define the most pressing research questions and how our knowledge of chronobiology can inform key translational research priorities.
Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Circadian Rhythm
/
Circadian Clocks
/
SARS-CoV-2
/
COVID-19
/
Immune System
Type of study:
Observational study
Limits:
Animals
/
Humans
Language:
English
Journal:
J Biol Rhythms
Journal subject:
Physiology
Year:
2021
Document Type:
Article
Affiliation country:
0748730420987669
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