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Clocks, Viruses, and Immunity: Lessons for the COVID-19 Pandemic.
Sengupta, Shaon; Ince, Louise; Sartor, Francesca; Borrmann, Helene; Zhuang, Xiaodong; Naik, Amruta; Curtis, Annie; McKeating, Jane A.
  • Sengupta S; Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
  • Ince L; Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.
  • Sartor F; Institute of Translational Medicine and Therapeutics, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
  • Borrmann H; Chronobiology and Sleep Institute, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
  • Zhuang X; Departement de Pathologie et Immunologie, Geneva, Switzerland.
  • Naik A; Institute of Medical Psychology, Medical Faculty, Ludwig Maximilian University of Munich, Munich, Germany.
  • Curtis A; Nuffield Department of Medicine, University of Oxford, Oxford, UK.
  • McKeating JA; Nuffield Department of Medicine, University of Oxford, Oxford, UK.
J Biol Rhythms ; 36(1): 23-34, 2021 02.
Article in English | MEDLINE | ID: covidwho-1044068
ABSTRACT
Circadian rhythms are evolutionarily conserved anticipatory systems that allow the host to prepare and respond to threats in its environment. This article summarizes a European Biological Rhythms Society (EBRS) workshop held in July 2020 to review current knowledge of the interplay between the circadian clock and viral infections to inform therapeutic strategies against SARS-CoV-2 and COVID-19. A large body of work supports the role of the circadian clock in regulating various aspects of viral replication, host responses, and associated pathogenesis. We review the evidence describing the multifaceted role of the circadian clock, spanning host susceptibility, antiviral mechanisms, and host resilience. Finally, we define the most pressing research questions and how our knowledge of chronobiology can inform key translational research priorities.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Circadian Rhythm / Circadian Clocks / SARS-CoV-2 / COVID-19 / Immune System Type of study: Observational study Limits: Animals / Humans Language: English Journal: J Biol Rhythms Journal subject: Physiology Year: 2021 Document Type: Article Affiliation country: 0748730420987669

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Circadian Rhythm / Circadian Clocks / SARS-CoV-2 / COVID-19 / Immune System Type of study: Observational study Limits: Animals / Humans Language: English Journal: J Biol Rhythms Journal subject: Physiology Year: 2021 Document Type: Article Affiliation country: 0748730420987669