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Elevated Serum Pentraxin-3 Levels is Positively Correlated to Disease Severity and Coagulopathy in COVID-19 Patients.
Tong, Ming; Xiong, Ying; Zhu, Chen; Xu, Hong; Zheng, Qing; Hu, Changping; Jiang, Yu; Zou, Lianhong; Xiao, Xiaolin; Chen, Fang; Zhu, Yimin.
  • Tong M; Department of Infectious Diseases, The First-affiliated Hospital of Hunan Normal University (Hunan Provincial People's Hospital), Changsha, 410005, Hunan, China.
  • Xiong Y; School of Life Sciences, Hunan Normal University, Changsha, Hunan, China.
  • Zhu C; Institute of Emergency Medicine, Hunan Provincial Key Laboratory of Emergency and Critical Care Metabonomics, The First-affiliated Hospital of Hunan Normal University (Hunan Provincial People's Hospital), Changsha, 410005, Hunan, China.
  • Xu H; The Fourth People's Hospital of Yiyang, Yiyang, 413000, Hunan, China.
  • Zheng Q; Department of Pediatrics, Yiyang Central Hospital, Yiyang, Hunan 413099, P.R. China.
  • Hu C; The Fourth People's Hospital of Yiyang, Yiyang, 413000, Hunan, China.
  • Jiang Y; Department of Geriatrics, The First-affiliated Hospital of Hunan Normal University (Hunan Provincial People's Hospital), Changsha, 410005, Hunan, China.
  • Zou L; Department of Pharmacology, Xiangya School of Pharmaceutical Sciences, Central South University, Changsha 410078, Hunan, China.
  • Xiao X; Institute of Emergency Medicine, Hunan Provincial Key Laboratory of Emergency and Critical Care Metabonomics, The First-affiliated Hospital of Hunan Normal University (Hunan Provincial People's Hospital), Changsha, 410005, Hunan, China.
  • Chen F; Institute of Emergency Medicine, Hunan Provincial Key Laboratory of Emergency and Critical Care Metabonomics, The First-affiliated Hospital of Hunan Normal University (Hunan Provincial People's Hospital), Changsha, 410005, Hunan, China.
  • Zhu Y; The Fourth People's Hospital of Yiyang, Yiyang, 413000, Hunan, China.
Mediterr J Hematol Infect Dis ; 13(1): e2021015, 2021.
Article in English | MEDLINE | ID: covidwho-1045343
ABSTRACT

BACKGROUND:

Coronavirus disease 2019 (COVID-19) is highly contagious and deadly and is associated with coagulopathy. Pentraxin-3(PTX3) participates in innate resistance to infections and plays a role in thrombogenesis.

PURPOSE:

The present study aimed to investigate the role of PTX3 in coagulopathy in patients with COVID-19.

METHODS:

A retrospective study, including thirty-nine COVID-19 patients, enrolled in Hunan, China, were performed. The patients were classified into the D-dimer_L (D-dimer <1mg/L) and D-dimer_H (D-dimer≥1mg/L) groups basing on the plasma D-dimer levels on admission. Serum PTX3 levels were detected by enzyme-linked immunosorbent assays and compared between those two groups, then receiver operating characteristic (ROC) curve analysis, correlation analysis, and linear regression models were performed to analyze the association between PTX3 and D-dimer.

RESULTS:

Our results showed that serum PTX3 levels (median values, 10.21 vs. 3.36, P<0.001), computerized chest tomography (C.T.) scores (median values, 10.0 vs. 9.0, P<0.05), and length of stay (LOS) (mean values, 16.0 vs. 10.7, P=0.001) in the D-dimer_H group were significantly higher than that in D-dimer_L group. ROC curve analysis revealed that the AUC of white blood corpuscle counts, C-reaction protein, erythrocyte sedimentation rate, and PTX3 for COVID-19 were 0.685, 0.863, 0.846, and 0.985, respectively. Correlation analysis showed that there was a positive relationship between PTX3 and D-dimer (r=0.721, P<0.001), chest CT imaging score (r=0.418, P=0.008), and LOS (r=0.486, P=0.002). Multiple linear regression analysis showed that the coefficient of determination was 0.657 (P < 0.001).

CONCLUSION:

Serum level of PTX3 was positively correlated with disease severity and coagulopathy. Detection of serum PTX3 level could help identify severer patients on admission and may be a potential therapeutic target for coagulopathy in patients with COVID-19.
Keywords

Full text: Available Collection: International databases Database: MEDLINE Type of study: Experimental Studies / Observational study / Prognostic study / Randomized controlled trials Language: English Journal: Mediterr J Hematol Infect Dis Year: 2021 Document Type: Article Affiliation country: MJHID.2021.015

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Full text: Available Collection: International databases Database: MEDLINE Type of study: Experimental Studies / Observational study / Prognostic study / Randomized controlled trials Language: English Journal: Mediterr J Hematol Infect Dis Year: 2021 Document Type: Article Affiliation country: MJHID.2021.015