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Coronavirus Disease 2019 (COVID-19) in Italy: Double Reading of Chest CT Examination.
Reginelli, Alfonso; Grassi, Roberta; Feragalli, Beatrice; Belfiore, Maria Paola; Montanelli, Alessandro; Patelli, Gianluigi; La Porta, Michelearcangelo; Urraro, Fabrizio; Fusco, Roberta; Granata, Vincenza; Petrillo, Antonella; Giacobbe, Giuliana; Russo, Gaetano Maria; Sacco, Palmino; Grassi, Roberto; Cappabianca, Salvatore.
  • Reginelli A; Department of Precision Medicine, Università degli Studi della Campania Luigi Vanvitelli, 80121 Naples, Italy.
  • Grassi R; Department of Precision Medicine, Università degli Studi della Campania Luigi Vanvitelli, 80121 Naples, Italy.
  • Feragalli B; Oral and Biotechnological Sciences-Radiology Unit "G. D'Annunzio", Department of Medical, University of Chieti-Pescara, 66100 Chieti, Italy.
  • Belfiore MP; Department of Precision Medicine, Università degli Studi della Campania Luigi Vanvitelli, 80121 Naples, Italy.
  • Montanelli A; Laboratory Medicine Unit, ASST Bergamo Est, 24068 Seriate, Italy.
  • Patelli G; Department of Radiology, ASST Bergamo Est, 24068 Seriate, Italy.
  • La Porta M; Department of Radiology, UOC San Severo Hospital, 71016 San Severo, Italy.
  • Urraro F; Department of Precision Medicine, Università degli Studi della Campania Luigi Vanvitelli, 80121 Naples, Italy.
  • Fusco R; Radiology Division, Istituto Nazionale Tumori IRCCS Fondazione Pascale-IRCCS di Napoli, 80131 Naples, Italy.
  • Granata V; Radiology Division, Istituto Nazionale Tumori IRCCS Fondazione Pascale-IRCCS di Napoli, 80131 Naples, Italy.
  • Petrillo A; Radiology Division, Istituto Nazionale Tumori IRCCS Fondazione Pascale-IRCCS di Napoli, 80131 Naples, Italy.
  • Giacobbe G; Department of Precision Medicine, Università degli Studi della Campania Luigi Vanvitelli, 80121 Naples, Italy.
  • Russo GM; Department of Precision Medicine, Università degli Studi della Campania Luigi Vanvitelli, 80121 Naples, Italy.
  • Sacco P; Diagnostic Imaging Unit, Department of Radiological Sciences, Azienda Ospedaliera Universitaria Senese, 53100 Siena, Italy.
  • Grassi R; Department of Precision Medicine, Università degli Studi della Campania Luigi Vanvitelli, 80121 Naples, Italy.
  • Cappabianca S; Foundation SIRM, 20122 Milan, Italy.
Biology (Basel) ; 10(2)2021 Jan 25.
Article in English | MEDLINE | ID: covidwho-1045466
Semantic information from SemMedBD (by NLM)
1. Performance PROCESS_OF Patients
Subject
Performance
Predicate
PROCESS_OF
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Patients
2. Discordance PROCESS_OF Patients
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Discordance
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3. tomography ADMINISTERED_TO radiologist
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tomography
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radiologist
4. radiologist DIAGNOSES COVID-19
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radiologist
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COVID-19
5. COVID-19 PROCESS_OF Patients
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6. Confidence PROCESS_OF Patients
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7. Performance PROCESS_OF Patients
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8. Discordance PROCESS_OF Patients
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9. tomography ADMINISTERED_TO radiologist
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10. radiologist DIAGNOSES COVID-19
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11. COVID-19 PROCESS_OF Patients
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12. Confidence PROCESS_OF Patients
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ABSTRACT
To assess the performance of the second reading of chest compute tomography (CT) examinations by expert radiologists in patients with discordance between the reverse transcription real-time fluorescence polymerase chain reaction (RT-PCR) test for COVID-19 viral pneumonia and the CT report. Three hundred and seventy-eight patients were included in this retrospective study (121 women and 257 men; 71 years median age, with a range of 29-93 years) and subjected to RT-PCR tests for suspicious COVID-19 infection. All patients were subjected to CT examination in order to evaluate the pulmonary disease involvement by COVID-19. CT images were reviewed first by two radiologists who identified COVID-19 typical CT patterns and then reanalyzed by another two radiologists using a CT structured report for COVID-19 diagnosis. Weighted к values were used to evaluate the inter-reader agreement. The median temporal window between RT-PCRs execution and CT scan was zero days with a range of (-9,11) days. The RT-PCR test was positive in 328/378 (86.8%). Discordance between RT-PCR and CT findings for viral pneumonia was revealed in 60 cases. The second reading changed the CT diagnosis in 16/60 (26.7%) cases contributing to an increase the concordance with the RT-PCR. Among these 60 cases, eight were false negative with positive RT-PCR, and 36 were false positive with negative RT-PCR. Sensitivity, specificity, positive predictive value and negative predictive value of CT were respectively of 97.3%, 53.8%, 89.0%, and 88.4%. Double reading of CT scans and expert second readers could increase the diagnostic confidence of radiological interpretation in COVID-19 patients.
Keywords

Full text: Available Collection: International databases Database: MEDLINE Type of study: Observational study / Prognostic study / Risk factors Language: English Year: 2021 Document Type: Article Affiliation country: Biology10020089

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Full text: Available Collection: International databases Database: MEDLINE Type of study: Observational study / Prognostic study / Risk factors Language: English Year: 2021 Document Type: Article Affiliation country: Biology10020089