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Cyclodextrin pendant polymer as an efficient drug carrier for scutellarin.
Liao, Rongqiang; Liu, Ying; Lv, Pin; Wu, Di; Xu, Meiling; Zheng, Xiaoyuan.
  • Liao R; Pharmacy Department, Chongqing Emergency Medical Center, Chongqing University Central Hospital, Chongqing, P.R. China.
  • Liu Y; Pharmacy Department, Chongqing Emergency Medical Center, Chongqing University Central Hospital, Chongqing, P.R. China.
  • Lv P; Industrial Crop Research Institute, Yunnan Academy of Agricultural Sciences, Kunming, P.R. China.
  • Wu D; Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming, P.R. China.
  • Xu M; Pharmacy Department, Chongqing Emergency Medical Center, Chongqing University Central Hospital, Chongqing, P.R. China.
  • Zheng X; Pharmacy Department, Chongqing Emergency Medical Center, Chongqing University Central Hospital, Chongqing, P.R. China.
Drug Deliv ; 27(1): 1741-1749, 2020 Nov 26.
Article in English | MEDLINE | ID: covidwho-1045942
ABSTRACT
A novel ß-cyclodextrin pendant polymer (ε-PL-CD), composed of poly(ε-lysine) (ε-PL) main chain and glycine-ß-cyclodextrin (Gly-CD) side chains, was prepared by a simple two-step procedure. The ε-PL-CD was investigated as a drug carrier of hydrophobic drug scutellarin (SCU). The characterization and complexation mode of the SCUε-PL-CD were researched in both solution and solid state by means of photoluminescence spectroscopy, 1H and 2D NMR, X-Ray powder diffraction (XRPD), thermal gravimetric analysis, Particle size and Zeta potential. The solubility test indicated that the solubilizing ability of SCUε-PL-CD was significantly improved compared with SCUß-CD and free SCU. Besides, in vitro cell experiment, it was found that SCUε-PL-CD has a strong inhibitory effect on the growth and invasion of tumor cells. The present study provides useful information for ε-PL-CD as a drug carrier material.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Drug Carriers / Cellulose / Cyclodextrins / Apigenin / Glucuronates Limits: Humans Language: English Journal: Drug Deliv Journal subject: Pharmacology / Drug Therapy Year: 2020 Document Type: Article

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Drug Carriers / Cellulose / Cyclodextrins / Apigenin / Glucuronates Limits: Humans Language: English Journal: Drug Deliv Journal subject: Pharmacology / Drug Therapy Year: 2020 Document Type: Article