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Antihistamine and cationic amphiphilic drugs, old molecules as new tools against the COVID-19?
Gitahy Falcao Faria, Clara; Weiner, Luisa; Petrignet, Julien; Hingray, Coraline; Ruiz De Pellon Santamaria, Ángel; Villoutreix, Bruno O; Beaune, Philippe; Leboyer, Marion; Javelot, Hervé.
  • Gitahy Falcao Faria C; Institute of Psychiatry, Federal University of Rio de Janeiro (UFRJ), Rio de Janeiro, Brazil; Clinique de Psychiatrie, CHU de Strasbourg, France.
  • Weiner L; Clinique de Psychiatrie, CHU de Strasbourg, France.
  • Petrignet J; Laboratoire Synthèse et Isolement de Molécules BioActives (SIMBA, EA 7502), Université de Tours, Faculté des Sciences et Techniques, Tours, France.
  • Hingray C; Pôle Hospitalo-Universitaire de Psychiatrie d'Adultes du Grand Nancy, Centre Psychothérapique de Nancy, Laxou, CHU de Nancy, Département de Neurologie, Nancy, France.
  • Ruiz De Pellon Santamaria Á; Department of Psychiatry, Donostia University Hospital,Donostia, Guipúzcoa, Spain.
  • Villoutreix BO; Université de Paris, NeuroDiderot, Inserm U1141, hôpital Robert-Debré, F-75019 Paris, France.
  • Beaune P; Inserm U 1138 Centre de recherche des Cordeliers 75006 Paris, Université de Paris, Paris, France.
  • Leboyer M; Université Paris Est Créteil (UPEC), INSERM U955, IMRB, Laboratoire Neuro-psychiatrie translationnelle, AP-HP, Département Medico-Universitaire de Psychiatrie et d'Addictologie (DMU ADAPT), Hôpital Henri Mondor, Fondation FondaMental, F-94010 Créteil, France.
  • Javelot H; Etablissement Public de Santé Alsace Nord, Brumath, France Laboratoire de Toxicologie et Pharmacologie Neuro Cardiovasculaire, Université de Strasbourg, Strasbourg, France. Electronic address: herve.javelot@ch-epsan.fr.
Med Hypotheses ; 148: 110508, 2021 Mar.
Article in English | MEDLINE | ID: covidwho-1046208
ABSTRACT
Several studies have reported that certain psychoactive drugs could have a protective effect against SARS-CoV-2. Herein, we propose that antihistamines (anti-H1) and cationic amphiphilic drugs (CAD), specifically, have the capacity to disrupt virus entry and replication. In addition, several of these molecules have limited side effects and as such could be promising prophylactic candidates against SARS-CoV-2 infection.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Surface-Active Agents / SARS-CoV-2 / COVID-19 Drug Treatment / Histamine H1 Antagonists Limits: Humans Language: English Journal: Med Hypotheses Year: 2021 Document Type: Article Affiliation country: J.mehy.2021.110508

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Surface-Active Agents / SARS-CoV-2 / COVID-19 Drug Treatment / Histamine H1 Antagonists Limits: Humans Language: English Journal: Med Hypotheses Year: 2021 Document Type: Article Affiliation country: J.mehy.2021.110508