A Narrative Review of Pharmacologic Treatments for COVID-19: Safety Considerations and Ototoxicity.
Laryngoscope
; 131(7): 1626-1632, 2021 07.
Article
in English
| MEDLINE | ID: covidwho-1046819
ABSTRACT
OBJECTIVE/HYPOTHESIS:
The purpose of this review is to summarize evidence-based data regarding the ototoxic effects of potential COVID-19 therapeutics to treat patients suffering from SARS-CoV-2.METHODS:
Medications under investigation as novel therapeutics to treat COVID-19 were identified using the search term coronavirus therapeutics, COVID therapeutics, and SARS-CoV-2 therapeutics on ClinicalTrials.gov and the PubMed Database. A literature review was performed using the PubMed Database for each proposed COVID-19 therapeutic to identify relevant articles. Search criteria included Medical Subject Headings (MeSH) and key word search terms for ototoxicity, vestibulotoxicity, hearing disorders, and vertigo.RESULTS:
Six proposed COVID-19 therapeutics were identified as possessing ototoxic side effects including chloroquine and hydroxychloroquine, azithromycin, lopinavir-ritonavir, interferon, ribavirin, and ivermectin.CONCLUSIONS:
Available evidence suggests that ototoxic effects may be improved or mitigated by stopping the offending agent. Recognition of hearing loss, tinnitus, or imbalance/vertigo is therefore crucial to facilitate early intervention and prevent long-term damage. Hospitals should consider the inclusion of audiologic monitoring protocols for patients receiving COVID-19 therapeutics with known ototoxicity, especially in high-risk patient groups such as the elderly and hearing impaired. Laryngoscope, 1311626-1632, 2021.Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Ototoxicity
/
COVID-19 Drug Treatment
Type of study:
Experimental Studies
/
Prognostic study
/
Randomized controlled trials
/
Reviews
Topics:
Long Covid
Limits:
Humans
Language:
English
Journal:
Laryngoscope
Journal subject:
Otolaryngology
Year:
2021
Document Type:
Article
Affiliation country:
Lary.29424
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