Acute necrotizing glomerulonephritis associated with COVID-19 infection: report of two pediatric cases.
Pediatr Nephrol
; 36(4): 1019-1023, 2021 04.
Article
in English
| MEDLINE | ID: covidwho-1047246
ABSTRACT
BACKGROUND:
Coronavirus disease 2019 (COVID-19) is thought to cause kidney injury via a variety of mechanisms. The most common reported kidney injury following COVID-19 infection is acute tubular injury (ATI); however, the procoagulant state induced by the virus may also damage the kidneys. CASE-DIAGNOSIS/TREATMENT Herein, we report two cases of acute necrotizing glomerulonephritis (GN) with fibrinoid necrosis in the context of COVID-19 infection. The one with more chronic features in the kidney biopsy progressed to permanent kidney failure but the second one had an excellent response to glucocorticoid pulse therapy with subsequent normal kidney function at 2-month follow-up.CONCLUSIONS:
Both reported cases had an acute presentation of kidney injury with positive nasopharyngeal PCR test for COVID-19. Based on the data review by the researchers, this is the first report of acute necrotizing GN associated with COVID-19 infection.Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Acute Kidney Injury
/
SARS-CoV-2
/
COVID-19
/
Glomerulonephritis
/
Kidney Glomerulus
Type of study:
Case report
/
Cohort study
/
Diagnostic study
/
Prognostic study
Topics:
Long Covid
Limits:
Adolescent
/
Humans
/
Male
Language:
English
Journal:
Pediatr Nephrol
Journal subject:
Nephrology
/
Pediatrics
Year:
2021
Document Type:
Article
Affiliation country:
S00467-021-04944-w
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