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The relationship between positivity for COVID-19 RT-PCR and symptoms, clinical findings, and mortality in Turkey.
Ozcan, Erkan; Yavuzer, Serap; Borku Uysal, Betul; Islamoglu, Mehmet Sami; Ikitimur, Hande; Unal, Omer Faruk; Akpinar, Yunus Emre; Seyhan, Serhat; Koc, Suna; Yavuzer, Hakan; Cengiz, Mahir.
  • Ozcan E; Department of Internal Medicine, Division of Oncology, Medical Faculty, Trakya University, Edirne, Turkey.
  • Yavuzer S; Department of Internal Medicine, Biruni University Medical Faculty, Istanbul, Turkey.
  • Borku Uysal B; Department of Internal Medicine, Biruni University Medical Faculty, Istanbul, Turkey.
  • Islamoglu MS; Department of Internal Medicine, Biruni University Medical Faculty, Istanbul, Turkey.
  • Ikitimur H; Department of Pulmonary Diseases, Biruni University Medical Faculty, Istanbul, Turkey.
  • Unal OF; Department of Radiology, Biruni University Medical Faculty, Istanbul, Turkey.
  • Akpinar YE; Department of Radiology, Biruni University Medical Faculty, Istanbul, Turkey.
  • Seyhan S; Department of Medical Genetics, Biruni University Medical Faculty, Istanbul, Turkey.
  • Koc S; Department of Anesthesiology and Reanimation, Biruni University Medical Faculty, Istanbul, Turkey.
  • Yavuzer H; Department of Internal Medicine, Division of Geriatrics, Cerrahpasa School of Medicine, Istanbul University-Cerrahpasa, Istanbul, Turkey.
  • Cengiz M; Department of Internal Medicine, Biruni University Medical Faculty, Istanbul, Turkey.
Expert Rev Mol Diagn ; 21(2): 245-250, 2021 02.
Article in English | MEDLINE | ID: covidwho-1048072
ABSTRACT

Introduction:

This study aimed to assess the correlation between nucleic acid amplification test (real-time reverse transcription-polymerase chain reaction, RT-PCR) positivity of patients presenting with suspected COVID-19 and pneumonic infiltration consistent with COVID-19-specific pneumonia diagnosis on thoracic computed tomography (CT), with symptoms, laboratory findings, and clinical progression.

Methods:

The study included 286 patients (femalemale 131155; mean age, 53.3 ± 17.9 years) who were divided into two groups according to their RT-PCR test results. The symptoms, laboratory examinations, clinical findings, and thoracic CT imaging of the patients were evaluated.

Results:

While the physical examination, comorbidities, and total CT scores were similar between the groups, taste/smell abnormalities were observed more frequently in the PCR-positive group. The use of moxifloxacin, lopinavir/ritonavir, and tocilizumab was higher in the PCR-positive group (p = 0.016, p < 0.001, and p = 0.002, respectively). The duration of hospitalization, intensive care requirement, and mortality rate of the studied groups did not differ between the groups.

Conclusions:

Among patients presenting with suspected COVID-19 and pneumonic infiltration consistent with COVID-19 on thoracic CT, the symptoms, physical examination, total CT scores, duration of hospitalization, intensive care requirement, and mortality rate were similar between RT-PCR-positive and RT-PCR-negative patients. However, PCR-positive patients appeared to require more specific treatments.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Real-Time Polymerase Chain Reaction / COVID-19 Nucleic Acid Testing / COVID-19 Type of study: Diagnostic study / Experimental Studies / Observational study / Prognostic study / Randomized controlled trials Topics: Long Covid Limits: Adult / Aged / Female / Humans / Male / Middle aged Country/Region as subject: Asia Language: English Journal: Expert Rev Mol Diagn Journal subject: Molecular Biology Year: 2021 Document Type: Article Affiliation country: 14737159.2021.1882305

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Real-Time Polymerase Chain Reaction / COVID-19 Nucleic Acid Testing / COVID-19 Type of study: Diagnostic study / Experimental Studies / Observational study / Prognostic study / Randomized controlled trials Topics: Long Covid Limits: Adult / Aged / Female / Humans / Male / Middle aged Country/Region as subject: Asia Language: English Journal: Expert Rev Mol Diagn Journal subject: Molecular Biology Year: 2021 Document Type: Article Affiliation country: 14737159.2021.1882305