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The InterPro protein families and domains database: 20 years on.
Blum, Matthias; Chang, Hsin-Yu; Chuguransky, Sara; Grego, Tiago; Kandasaamy, Swaathi; Mitchell, Alex; Nuka, Gift; Paysan-Lafosse, Typhaine; Qureshi, Matloob; Raj, Shriya; Richardson, Lorna; Salazar, Gustavo A; Williams, Lowri; Bork, Peer; Bridge, Alan; Gough, Julian; Haft, Daniel H; Letunic, Ivica; Marchler-Bauer, Aron; Mi, Huaiyu; Natale, Darren A; Necci, Marco; Orengo, Christine A; Pandurangan, Arun P; Rivoire, Catherine; Sigrist, Christian J A; Sillitoe, Ian; Thanki, Narmada; Thomas, Paul D; Tosatto, Silvio C E; Wu, Cathy H; Bateman, Alex; Finn, Robert D.
  • Blum M; European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Genome Campus, Hinxton, Cambridgeshire CB10 1SD, UK.
  • Chang HY; European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Genome Campus, Hinxton, Cambridgeshire CB10 1SD, UK.
  • Chuguransky S; European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Genome Campus, Hinxton, Cambridgeshire CB10 1SD, UK.
  • Grego T; European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Genome Campus, Hinxton, Cambridgeshire CB10 1SD, UK.
  • Kandasaamy S; European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Genome Campus, Hinxton, Cambridgeshire CB10 1SD, UK.
  • Mitchell A; European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Genome Campus, Hinxton, Cambridgeshire CB10 1SD, UK.
  • Nuka G; European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Genome Campus, Hinxton, Cambridgeshire CB10 1SD, UK.
  • Paysan-Lafosse T; European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Genome Campus, Hinxton, Cambridgeshire CB10 1SD, UK.
  • Qureshi M; European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Genome Campus, Hinxton, Cambridgeshire CB10 1SD, UK.
  • Raj S; European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Genome Campus, Hinxton, Cambridgeshire CB10 1SD, UK.
  • Richardson L; European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Genome Campus, Hinxton, Cambridgeshire CB10 1SD, UK.
  • Salazar GA; European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Genome Campus, Hinxton, Cambridgeshire CB10 1SD, UK.
  • Williams L; European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Genome Campus, Hinxton, Cambridgeshire CB10 1SD, UK.
  • Bork P; European Molecular Biology Laboratory, Structural and Computational Biology Unit, Meyerhofstraße 1, 69117 Heidelberg, Germany.
  • Bridge A; Swiss-Prot Group, Swiss Institute of Bioinformatics, CMU, 1 rue Michel Servet, CH-1211, Geneva 4, Switzerland.
  • Gough J; Medical Research Council Laboratory of Molecular Biology, Cambridge Biomedical Campus, Francis Crick Ave, Trumpington, Cambridge CB2 0QH, UK.
  • Haft DH; National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, 8600 Rockville Pike, Bethesda MD 20894 USA.
  • Letunic I; Biobyte Solutions GmbH, Bothestr 142, 69126 Heidelberg, Germany.
  • Marchler-Bauer A; National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, 8600 Rockville Pike, Bethesda MD 20894 USA.
  • Mi H; Division of Bioinformatics, Department of Preventive Medicine, University of Southern California, Los Angeles, CA 90033, USA.
  • Natale DA; Protein Information Resource, Georgetown University Medical Center, Washington, DC 20007, USA.
  • Necci M; Department of Biomedical Sciences, University of Padua, via U. Bassi 58/b, 35131 Padua, Italy.
  • Orengo CA; Department of Structural and Molecular Biology, University College London, Gower St, Bloomsbury, London WC1E 6BT, UK.
  • Pandurangan AP; Medical Research Council Laboratory of Molecular Biology, Cambridge Biomedical Campus, Francis Crick Ave, Trumpington, Cambridge CB2 0QH, UK.
  • Rivoire C; Swiss-Prot Group, Swiss Institute of Bioinformatics, CMU, 1 rue Michel Servet, CH-1211, Geneva 4, Switzerland.
  • Sigrist CJA; Swiss-Prot Group, Swiss Institute of Bioinformatics, CMU, 1 rue Michel Servet, CH-1211, Geneva 4, Switzerland.
  • Sillitoe I; Department of Structural and Molecular Biology, University College London, Gower St, Bloomsbury, London WC1E 6BT, UK.
  • Thanki N; National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, 8600 Rockville Pike, Bethesda MD 20894 USA.
  • Thomas PD; Division of Bioinformatics, Department of Preventive Medicine, University of Southern California, Los Angeles, CA 90033, USA.
  • Tosatto SCE; Department of Biomedical Sciences, University of Padua, via U. Bassi 58/b, 35131 Padua, Italy.
  • Wu CH; Protein Information Resource, Georgetown University Medical Center, Washington, DC 20007, USA.
  • Bateman A; European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Genome Campus, Hinxton, Cambridgeshire CB10 1SD, UK.
  • Finn RD; European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Genome Campus, Hinxton, Cambridgeshire CB10 1SD, UK.
Nucleic Acids Res ; 49(D1): D344-D354, 2021 01 08.
Article in English | MEDLINE | ID: covidwho-1048363
ABSTRACT
The InterPro database (https//www.ebi.ac.uk/interpro/) provides an integrative classification of protein sequences into families, and identifies functionally important domains and conserved sites. InterProScan is the underlying software that allows protein and nucleic acid sequences to be searched against InterPro's signatures. Signatures are predictive models which describe protein families, domains or sites, and are provided by multiple databases. InterPro combines signatures representing equivalent families, domains or sites, and provides additional information such as descriptions, literature references and Gene Ontology (GO) terms, to produce a comprehensive resource for protein classification. Founded in 1999, InterPro has become one of the most widely used resources for protein family annotation. Here, we report the status of InterPro (version 81.0) in its 20th year of operation, and its associated software, including updates to database content, the release of a new website and REST API, and performance improvements in InterProScan.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Proteins / Databases, Protein Type of study: Prognostic study Language: English Journal: Nucleic Acids Res Year: 2021 Document Type: Article Affiliation country: Nar

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Proteins / Databases, Protein Type of study: Prognostic study Language: English Journal: Nucleic Acids Res Year: 2021 Document Type: Article Affiliation country: Nar