Regional and Chronological Variation of Chemosensory Dysfunction in COVID-19: a Meta-Analysis.
J Korean Med Sci
; 36(4): e40, 2021 Jan 25.
Article
in English
| MEDLINE | ID: covidwho-1048952
ABSTRACT
BACKGROUND:
Olfactory and gustatory dysfunction are frequently reported in patients with coronavirus disease 2019 (COVID-19). However, the reported prevalence of olfactory and/or gustatory dysfunction varies widely, and the reason for the inter-study differences is unclear. Hence, in this meta-analysis, we performed subgroup analyses to investigate the factors that contribute to the inter-study variability in the prevalence of olfactory and gustatory dysfunction.METHODS:
Out of 943 citations, we included 55 eligible studies with 13,527 patients with COVID-19 for a meta-analysis. Calculating the data extracted from each study, the weighted summary prevalence of olfactory and gustatory dysfunction was estimated using a Freeman-Tukey transformation with models based on random-effects assumptions. A meta-analysis of variance compared the prevalence of olfactory and gustatory dysfunction according to regional, chronological, demographic, and methodologic factors, respectively.RESULTS:
The overall pooled prevalence rates of olfactory and gustatory dysfunction were 51.4% and 47.5%, respectively, in the random-effect model. In subgroup analyses, the prevalence rates of olfactory and gustatory dysfunction were significantly different among four geographical regions (both P < 0.001, respectively). Although the prevalence rates of olfactory and gustatory dysfunction did not significantly differ according to the time of enrollment, the subgroup analyses including only studies from the same geographical region (Europe) revealed a significant difference in olfactory dysfunction according to the time of enrollment.CONCLUSION:
The regional and chronological differences in the prevalence rates of olfactory and gustatory dysfunctions partly explain the wide inter-study variability.Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Taste Disorders
/
COVID-19
/
Olfaction Disorders
Type of study:
Diagnostic study
/
Observational study
/
Randomized controlled trials
/
Reviews
Limits:
Humans
Country/Region as subject:
Europa
Language:
English
Journal:
J Korean Med Sci
Journal subject:
Medicine
Year:
2021
Document Type:
Article
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