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A review on possible mechanistic insights of Nitazoxanide for repurposing in COVID-19.
Lokhande, Amit S; Devarajan, Padma V.
  • Lokhande AS; Department of Pharmaceutical Sciences and Technology, Institute of Chemical Technology, N. P. Marg, Matunga, Mumbai, 400019, Maharashtra, India.
  • Devarajan PV; Department of Pharmaceutical Sciences and Technology, Institute of Chemical Technology, N. P. Marg, Matunga, Mumbai, 400019, Maharashtra, India. Electronic address: pvdevarajan@gmail.com.
Eur J Pharmacol ; 891: 173748, 2021 Jan 15.
Article in English | MEDLINE | ID: covidwho-1049786
ABSTRACT
The global pandemic of Coronavirus Disease 2019 (COVID-19) has brought the world to a grinding halt. A major cause of concern is the respiratory distress associated mortality attributed to the cytokine storm. Despite myriad rapidly approved clinical trials with repurposed drugs, and time needed to develop a vaccine, accelerated search for repurposed therapeutics is still ongoing. In this review, we present Nitazoxanide a US-FDA approved antiprotozoal drug, as one such promising candidate. Nitazoxanide which is reported to exert broad-spectrum antiviral activity against various viral infections, revealed good in vitro activity against SARS-CoV-2 in cell culture assays, suggesting potential for repurposing in COVID-19. Furthermore, nitazoxanide displays the potential to boost host innate immune responses and thereby tackle the life-threatening cytokine storm. Possibilities of improving lung, as well as multiple organ damage and providing value addition to COVID-19 patients with comorbidities, are other important facets of the drug. The review juxtaposes the role of nitazoxanide in fighting COVID-19 pathogenesis at multiple levels highlighting the great promise the drug exhibits. The in silico data and in vitro efficacy in cell lines confirms the promise of nitazoxanide. Several approved clinical trials world over further substantiate leveraging nitazoxanide for COVID-19 therapy.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Thiazoles / Drug Repositioning / SARS-CoV-2 / COVID-19 / COVID-19 Drug Treatment Type of study: Prognostic study / Randomized controlled trials Topics: Vaccines Limits: Humans Language: English Journal: Eur J Pharmacol Year: 2021 Document Type: Article Affiliation country: J.ejphar.2020.173748

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Thiazoles / Drug Repositioning / SARS-CoV-2 / COVID-19 / COVID-19 Drug Treatment Type of study: Prognostic study / Randomized controlled trials Topics: Vaccines Limits: Humans Language: English Journal: Eur J Pharmacol Year: 2021 Document Type: Article Affiliation country: J.ejphar.2020.173748