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The lung-gut axis during viral respiratory infections: the impact of gut dysbiosis on secondary disease outcomes.
Sencio, Valentin; Machado, Marina Gomes; Trottein, François.
  • Sencio V; US 41-UMS 2014-PLBS, U1019-UMR 9017-CIIL-Centre d'Infection et d'Immunité de Lille, Univ. Lille, F-59000, Lille, France.
  • Machado MG; Centre National de la Recherche Scientifique, UMR 9017, F-59000, Lille, France.
  • Trottein F; Institut National de la Santé et de la Recherche Médicale, U1019, F-59000, Lille, France.
Mucosal Immunol ; 14(2): 296-304, 2021 03.
Article in English | MEDLINE | ID: covidwho-1049958
ABSTRACT
Bacteria that colonize the human gastrointestinal tract are essential for good health. The gut microbiota has a critical role in pulmonary immunity and host's defense against viral respiratory infections. The gut microbiota's composition and function can be profoundly affected in many disease settings, including acute infections, and these changes can aggravate the severity of the disease. Here, we discuss mechanisms by which the gut microbiota arms the lung to control viral respiratory infections. We summarize the impact of viral respiratory infections on the gut microbiota and discuss the potential mechanisms leading to alterations of gut microbiota's composition and functions. We also discuss the effects of gut microbial imbalance on disease outcomes, including gastrointestinal disorders and secondary bacterial infections. Lastly, we discuss the potential role of the lung-gut axis in coronavirus disease 2019.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Gastrointestinal Microbiome / Lung Type of study: Experimental Studies / Prognostic study Limits: Animals / Humans Language: English Journal: Mucosal Immunol Journal subject: Allergy and Immunology Year: 2021 Document Type: Article Affiliation country: S41385-020-00361-8

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Gastrointestinal Microbiome / Lung Type of study: Experimental Studies / Prognostic study Limits: Animals / Humans Language: English Journal: Mucosal Immunol Journal subject: Allergy and Immunology Year: 2021 Document Type: Article Affiliation country: S41385-020-00361-8