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Mannose binding lectin gene 2 (rs1800450) missense variant may contribute to development and severity of COVID-19 infection.
Medetalibeyoglu, Alpay; Bahat, Gulistan; Senkal, Naci; Kose, Murat; Avci, Kader; Sayin, Gozde Yesil; Isoglu-Alkac, Ummuhan; Tukek, Tufan; Pehlivan, Sacide.
  • Medetalibeyoglu A; Department of Internal Medicine, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey.
  • Bahat G; Department of Internal Medicine, Division of Geriatrics, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey. Electronic address: gbahatozturk@yahoo.com.
  • Senkal N; Department of Internal Medicine, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey.
  • Kose M; Department of Internal Medicine, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey.
  • Avci K; Department of Medical Biology, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey.
  • Sayin GY; Department of Medical Genetics, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey.
  • Isoglu-Alkac U; Department of Physiology, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey.
  • Tukek T; Department of Internal Medicine, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey.
  • Pehlivan S; Department of Medical Biology, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey.
Infect Genet Evol ; 89: 104717, 2021 04.
Article in English | MEDLINE | ID: covidwho-1051857
Semantic information from SemMedBD (by NLM)
1. Comorbidity PROCESS_OF Older people
Subject
Comorbidity
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PROCESS_OF
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Older people
2. COVID-19 PROCESS_OF Patients
Subject
COVID-19
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Patients
3. Underlying PROCESS_OF Older people
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PROCESS_OF
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Older people
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DNA
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5. American College of Cardiology/American Heart Association Lesion Complexity Score C PROCESS_OF Patients
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American College of Cardiology/American Heart Association Lesion Complexity Score C
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Patients
6. AA genotype PROCESS_OF Patients
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AA genotype
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PROCESS_OF
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Patients
7. MBL2 gene|MBL2 COEXISTS_WITH B variant NOS
Subject
MBL2 gene|MBL2
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COEXISTS_WITH
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B variant NOS
8. B variant NOS PART_OF Persons
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B variant NOS
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Persons
9. Comorbidity PROCESS_OF Older people
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Comorbidity
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PROCESS_OF
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Older people
10. COVID-19 PROCESS_OF Patients
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11. Underlying PROCESS_OF Older people
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Older people
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13. American College of Cardiology/American Heart Association Lesion Complexity Score C PROCESS_OF Patients
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American College of Cardiology/American Heart Association Lesion Complexity Score C
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Patients
14. AA genotype PROCESS_OF Patients
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15. MBL2 gene|MBL2 COEXISTS_WITH B variant NOS
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B variant NOS
16. B variant NOS PART_OF Persons
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ABSTRACT
BACKGROUND/

OBJECTIVES:

COVID-19 followed a mortal course in some young patients without any underlying factors, however, it followed a very benign course in some very older individuals with multiple comorbidities. These observations question if some genetic factors may be related to the vulnerability and poor prognosis of the disease. In this study, we aimed to investigate whether MBL2 gene B variant at codon 54 (rs1800450) were related to the variabilities in clinical course of this infection.

METHODS:

284 PCR-confirmed COVID-19 patients and 100 healthy controls were included in the study. COVID-19 patients were subdivided according to the clinical features and clinical characteristics were analyzed. DNAs of all patients and controls were examined for the codon 54 A/B (gly54asp rs1800450) variation in exon 1 of the MBL2 gene.

RESULTS:

In univariate analysis, BB genotype of MBL2 gene was more common among COVID-19 cases compared with controls (10.9% vs 1.0%, respectively; OR = 12.1, 95%CI = 1.6-90.1, p = 0.001). Multivariate analyses, adjusted for age, sex and MBL genetic variants, revealed that when compared with the COVID-19 patients that had AA genotype (reference), the patients that had BB or AB genotypes suffered from a higher risk for severe disease (for BB genotype, odds ratio (OR) = 5.3, p < 0.001; for AB genotype, OR = 2.9, p = 0.001) and for ICU need (for BB genotype, OR = 19.6, p < 0.001; for AB genotype, OR = 6.9, p = 0.001). On the other hand, there was not any significant difference between the genotype variants in terms of mortality at 28 days or development of secondary bacterial infection.

CONCLUSION:

The B variants of MBL2 gene at codon 54, which were associated with lower MBL2 levels, were related to a higher risk for a more severe clinical course of COVID-19 infection in some respects. Our findings may have potential future implications, e.g. for use of MBL protein as potential therapeutics or prioritize the individuals with B variants during vaccination strategies.
Subject(s)
Keywords

Full text: Available Collection: International databases Database: MEDLINE Main subject: Mutation, Missense / Mannose-Binding Lectin / COVID-19 Type of study: Observational study / Prognostic study Topics: Vaccines / Variants Limits: Adult / Aged / Female / Humans / Male / Middle aged / Young adult Language: English Journal: Infect Genet Evol Journal subject: Biology / Communicable Diseases / Genetics Year: 2021 Document Type: Article Affiliation country: J.meegid.2021.104717

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Mutation, Missense / Mannose-Binding Lectin / COVID-19 Type of study: Observational study / Prognostic study Topics: Vaccines / Variants Limits: Adult / Aged / Female / Humans / Male / Middle aged / Young adult Language: English Journal: Infect Genet Evol Journal subject: Biology / Communicable Diseases / Genetics Year: 2021 Document Type: Article Affiliation country: J.meegid.2021.104717