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Thymosin Alpha 1 Mitigates Cytokine Storm in Blood Cells From Coronavirus Disease 2019 Patients.
Matteucci, Claudia; Minutolo, Antonella; Balestrieri, Emanuela; Petrone, Vita; Fanelli, Marialaura; Malagnino, Vincenzo; Ianetta, Marco; Giovinazzo, Alessandro; Barreca, Filippo; Di Cesare, Silvia; De Marco, Patrizia; Miele, Martino Tony; Toschi, Nicola; Mastino, Antonio; Sinibaldi Vallebona, Paola; Bernardini, Sergio; Rogliani, Paola; Sarmati, Loredana; Andreoni, Massimo; Grelli, Sandro; Garaci, Enrico.
  • Matteucci C; Department of Experimental Medicine, University of Rome Tor Vergata, Rome, Italy.
  • Minutolo A; Department of Experimental Medicine, University of Rome Tor Vergata, Rome, Italy.
  • Balestrieri E; Department of Experimental Medicine, University of Rome Tor Vergata, Rome, Italy.
  • Petrone V; Department of Experimental Medicine, University of Rome Tor Vergata, Rome, Italy.
  • Fanelli M; Department of Experimental Medicine, University of Rome Tor Vergata, Rome, Italy.
  • Malagnino V; Department of Systems Medicine, University of Rome Tor Vergata, Rome, Italy.
  • Ianetta M; Infectious Diseases Clinic, Policlinic of Tor Vergata, Rome, Italy.
  • Giovinazzo A; Department of Systems Medicine, University of Rome Tor Vergata, Rome, Italy.
  • Barreca F; Infectious Diseases Clinic, Policlinic of Tor Vergata, Rome, Italy.
  • Di Cesare S; Department of Experimental Medicine, University of Rome Tor Vergata, Rome, Italy.
  • De Marco P; Department of Systems Medicine, University of Rome Tor Vergata, Rome, Italy.
  • Miele MT; Infectious Diseases Clinic, Policlinic of Tor Vergata, Rome, Italy.
  • Toschi N; Department of Systems Medicine, University of Rome Tor Vergata, Rome, Italy.
  • Mastino A; Unit of Immune and Infectious Diseases, Academic Department of Pediatrics, Bambino Gesù Childrens' Hospital-Scientific Institute for Research and Healthcare (IRCCS), Rome, Italy.
  • Sinibaldi Vallebona P; Respiratory Medicine Unit, University Hospital Policlinico Tor Vergata, Rome, Italy.
  • Bernardini S; Department of Experimental Medicine, University of Rome Tor Vergata, Rome, Italy.
  • Rogliani P; Department of Biomedicine and Prevention, University of Rome Tor Vergata, Rome, Italy.
  • Sarmati L; Athinoula A. Martinos Center for Biomedical Imaging, Harvard Medical School, Boston, Massachusetts, USA.
  • Andreoni M; Institute of Translational Pharmacology, National Research Council, Rome, Italy.
  • Grelli S; Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, Messina, Italy.
  • Garaci E; Department of Experimental Medicine, University of Rome Tor Vergata, Rome, Italy.
Open Forum Infect Dis ; 8(1): ofaa588, 2021 Jan.
Article in English | MEDLINE | ID: covidwho-1052206
ABSTRACT

BACKGROUND:

Coronavirus disease 2019 (COVID-19) is characterized by immune-mediated lung injury and complex alterations of the immune system, such as lymphopenia and cytokine storm, that have been associated with adverse outcomes underlining a fundamental role of host response in severe acute respiratory syndrome coronavirus 2 infection and the pathogenesis of the disease. Thymosin alpha 1 (Tα1) is one of the molecules used in the management of COVID-19, because it is known to restore the homeostasis of the immune system during infections and cancer.

METHODS:

In this study, we captured the interconnected biological processes regulated by Tα1 in CD8+ T cells under inflammatory conditions.

RESULTS:

Genes associated with cytokine signaling and production were upregulated in blood cells from patients with COVID-19, and the ex vivo treatment with Tα1-mitigated cytokine expression, and inhibited lymphocyte activation in a CD8+ T-cell subset specifically.

CONCLUSION:

These data suggest the potential role of Tα1 in modulating the immune response homeostasis and the cytokine storm in vivo.
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Full text: Available Collection: International databases Database: MEDLINE Language: English Journal: Open Forum Infect Dis Year: 2021 Document Type: Article Affiliation country: Ofid

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Full text: Available Collection: International databases Database: MEDLINE Language: English Journal: Open Forum Infect Dis Year: 2021 Document Type: Article Affiliation country: Ofid