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Oral Bacteriotherapy in Patients With COVID-19: A Retrospective Cohort Study.
Ceccarelli, Giancarlo; Borrazzo, Cristian; Pinacchio, Claudia; Santinelli, Letizia; Innocenti, Giuseppe Pietro; Cavallari, Eugenio Nelson; Celani, Luigi; Marazzato, Massimiliano; Alessandri, Francesco; Ruberto, Franco; Pugliese, Francesco; Venditti, Mario; Mastroianni, Claudio M; d'Ettorre, Gabriella.
  • Ceccarelli G; Department of Public Health and Infectious Diseases, Sapienza University of Rome, Rome, Italy.
  • Borrazzo C; Azienda Ospedaliero-Universitaria Policlinico Umberto I, Rome, Italy.
  • Pinacchio C; Department of Public Health and Infectious Diseases, Sapienza University of Rome, Rome, Italy.
  • Santinelli L; Azienda Ospedaliero-Universitaria Policlinico Umberto I, Rome, Italy.
  • Innocenti GP; Medical Statistics Unit, Department of Public Health and Infectious Diseases, Sapienza University of Rome, Rome, Italy.
  • Cavallari EN; Department of Public Health and Infectious Diseases, Sapienza University of Rome, Rome, Italy.
  • Celani L; Department of Public Health and Infectious Diseases, Sapienza University of Rome, Rome, Italy.
  • Marazzato M; Department of Public Health and Infectious Diseases, Sapienza University of Rome, Rome, Italy.
  • Alessandri F; Department of Public Health and Infectious Diseases, Sapienza University of Rome, Rome, Italy.
  • Ruberto F; Azienda Ospedaliero-Universitaria Policlinico Umberto I, Rome, Italy.
  • Pugliese F; Department of Public Health and Infectious Diseases, Sapienza University of Rome, Rome, Italy.
  • Venditti M; Azienda Ospedaliero-Universitaria Policlinico Umberto I, Rome, Italy.
  • Mastroianni CM; Department of Public Health and Infectious Diseases, Sapienza University of Rome, Rome, Italy.
  • d'Ettorre G; Department of Anaesthesia and Intensive Care, Sapienza University of Rome, Rome, Italy.
Front Nutr ; 7: 613928, 2020.
Article in English | MEDLINE | ID: covidwho-1052491
Semantic information from SemMedBD (by NLM)
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Subject
COVID-19
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PROCESS_OF
Object
Patients
2. Epithelial Cells PART_OF Intestines
Subject
Epithelial Cells
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PART_OF
Object
Intestines
3. IMPACT gene INTERACTS_WITH Epithelial Cells
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IMPACT gene
Predicate
INTERACTS_WITH
Object
Epithelial Cells
4. COVID-19 AFFECTS Patients
Subject
COVID-19
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AFFECTS
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Patients
5. Hospitalization TREATS Pneumonia caused by SARS-CoV-2
Subject
Hospitalization
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TREATS
Object
Pneumonia caused by SARS-CoV-2
6. Pneumonia caused by SARS-CoV-2 PROCESS_OF Patients
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Pneumonia caused by SARS-CoV-2
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PROCESS_OF
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Patients
7. Hospitalization TREATS Patients
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Hospitalization
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TREATS
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Patients
8. Pneumonia caused by SARS-CoV-2 PROCESS_OF Adult
Subject
Pneumonia caused by SARS-CoV-2
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PROCESS_OF
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Adult
9. Therapeutic regimen ADMINISTERED_TO Patients
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Therapeutic regimen
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ADMINISTERED_TO
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Patients
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COVID-19
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PROCESS_OF
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Patients
11. Epithelial Cells PART_OF Intestines
Subject
Epithelial Cells
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PART_OF
Object
Intestines
12. IMPACT gene INTERACTS_WITH Epithelial Cells
Subject
IMPACT gene
Predicate
INTERACTS_WITH
Object
Epithelial Cells
13. COVID-19 AFFECTS Patients
Subject
COVID-19
Predicate
AFFECTS
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Patients
14. Hospitalization TREATS Pneumonia caused by SARS-CoV-2
Subject
Hospitalization
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TREATS
Object
Pneumonia caused by SARS-CoV-2
15. Pneumonia caused by SARS-CoV-2 PROCESS_OF Patients
Subject
Pneumonia caused by SARS-CoV-2
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PROCESS_OF
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Patients
16. Hospitalization TREATS Patients
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Hospitalization
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TREATS
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Patients
17. Pneumonia caused by SARS-CoV-2 PROCESS_OF Adult
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Pneumonia caused by SARS-CoV-2
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PROCESS_OF
Object
Adult
18. Therapeutic regimen ADMINISTERED_TO Patients
Subject
Therapeutic regimen
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ADMINISTERED_TO
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Patients
ABSTRACT

Background:

Mounting evidence suggests SARS-CoV-2 may impact on host microbiota and gut inflammation, infecting intestinal epithelial cells. This possible link and its implications can be investigated by observing the effects of modulation of the microbial flora in patients with COVID-19. The aim of this study was to compare the rate of mortality, the need of ICU hospitalization and the length of hospitalization in patients with severe COVID-19 pneumonia who received the best available therapy (BAT) vs. patients treated with BAT and supplemented with oral bacteriotherapy.

Methods:

This retrospective, observational cohort study included 200 adults with severe COVID-19 pneumonia. All patients received therapeutic regimens including low molecular weight heparin plus one or more between hydroxychloroquine, azithromycin, antivirals, and Tocilizumab. Oral bacteriotherapy was used as complementary treatment.

Results:

Out of the 200 patients, 112 received BAT without oral bacteriotherapy, and 88 BAT with oral bacteriotherapy. Crude mortality was 22%. Eleven percent died in the group of patients treated with BAT plus oral bacteriotherapy vs. 30% subjects in the group of patients managed only with BAT (p < 0.001). By multivariate analysis, the age >65 years, CRP >41.8 mg/L, Platelets <150.000 mmc, and cardiovascular events were associated with the increased risk of mortality. Oral bacteriotherapy was an independent variable associated with a reduced risk for death. Despite large prospective trials are needed, this study highlights a possible role for oral bacteriotherapy in the management of patients hospitalized for COVID-19 pneumonia.
Keywords

Full text: Available Collection: International databases Database: MEDLINE Type of study: Etiology study / Observational study / Risk factors Language: English Journal: Front Nutr Year: 2020 Document Type: Article Affiliation country: Fnut.2020.613928

Full text: Available Collection: International databases Database: MEDLINE Type of study: Etiology study / Observational study / Risk factors Language: English Journal: Front Nutr Year: 2020 Document Type: Article Affiliation country: Fnut.2020.613928