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COVID-19 and developmental origins of health and disease.
Forestieri, Stefano; Pintus, Roberta; Marcialis, Maria Antonietta; Pintus, Maria Cristina; Fanos, Vassilios.
  • Forestieri S; School of Pediatrics, University of Cagliari, Cagliari, Italy.
  • Pintus R; Department of Surgery, Neonatal Intensive Care Unit, University of Cagliari, Cagliari, Italy. Electronic address: gomberta@icloud.com.
  • Marcialis MA; Neonatal Intensive Care Unit, AOU, Cagliari, Cagliari, Italy.
  • Pintus MC; Neonatal Intensive Care Unit, AOU, Cagliari, Cagliari, Italy.
  • Fanos V; Department of Surgery, Neonatal Intensive Care Unit, University of Cagliari, Cagliari, Italy; Neonatal Intensive Care Unit, AOU, Cagliari, Cagliari, Italy.
Early Hum Dev ; 155: 105322, 2021 04.
Article in English | MEDLINE | ID: covidwho-1053333
ABSTRACT
From the moment of the identification of SARS-CoV-2 as an etiological agent of the severe clinical pictures of pneumonia that were being slowly observed all over the world, numerous studies have been conducted to increase the knowledge about what was an unknown virus until then. The efforts were mainly aimed to acquire epidemiological, microbiological, pathogenetic, clinical, diagnostic, therapeutic and preventive information in order to increase the available weapons to fight an infection which was rapidly taking on the characteristics of the pandemic. Given the topicality of the problem, not everything has yet been fully understood and clarified, especially in the maternal-fetal­neonatal field, where we are beginning to question what could be the outcomes of newborn babies born to mothers who contracted SARS-CoV-2 infection during pregnancy. Thus, the aim of this review is to analyze the long-term outcomes of this infection that could affect the offspring, regardless of a possible maternal-fetal transmission, focusing on, above all, the role of maternal immune activation and the expression of the Angiotensin-converting enzyme 2 (ACE2) in particular at the placental level.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pregnancy Complications, Infectious / COVID-19 / Infant, Newborn, Diseases Type of study: Etiology study / Prognostic study Topics: Long Covid Limits: Female / Humans / Infant, Newborn / Pregnancy Language: English Journal: Early Hum Dev Year: 2021 Document Type: Article Affiliation country: J.earlhumdev.2021.105322

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pregnancy Complications, Infectious / COVID-19 / Infant, Newborn, Diseases Type of study: Etiology study / Prognostic study Topics: Long Covid Limits: Female / Humans / Infant, Newborn / Pregnancy Language: English Journal: Early Hum Dev Year: 2021 Document Type: Article Affiliation country: J.earlhumdev.2021.105322