Gut microbiota in antiviral strategy from bats to humans: a missing link in COVID-19.
Sci China Life Sci
; 64(6): 942-956, 2021 06.
Article
in English
| MEDLINE | ID: covidwho-1056056
ABSTRACT
Bats are a potential natural reservoir for SARS-CoV-2 virus and other viruses detrimental to humans. Accumulated evidence has shown that, in their adaptation to a flight-based lifestyle, remodeling of the gut microbiota in bats may have contributed to immune tolerance to viruses. This evidence from bats provides profound insights into the potential influence of gut microbiota in COVID-19 disease in humans. Here, we highlight recent advances in our understanding of the mechanisms by which the gut microbiota helps bats tolerate deadly viruses, and summarize the current clinical evidence on the influence of gut microbiota on the susceptibility to SARS-CoV-2 infection and risk of COVID-19 leading to a fatal outcome. In addition, we discuss the implications of gut microbiota-targeted approaches for preventing infection and reducing disease severity in COVID-19 patients.
Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Disease Reservoirs
/
Chiroptera
/
Gastrointestinal Microbiome
/
COVID-19
Type of study:
Prognostic study
Limits:
Animals
/
Humans
Language:
English
Journal:
Sci China Life Sci
Journal subject:
Biology
/
Science
Year:
2021
Document Type:
Article
Affiliation country:
S11427-020-1847-7
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