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Efficacy and safety assessment of severe COVID-19 patients with Chinese medicine: A retrospective case series study at early stage of the COVID-19 epidemic in Wuhan, China.
Wang, Yu; Lu, Cheng; Li, Hao; Qi, Wensheng; Ruan, Lianguo; Bian, Yongjun; Shi, Huaxin; Song, Hui; Tu, Shengjin; Zhang, Yan; Bai, Tao; Cao, Rong; Hong, Ke; Li, Huadong; Liu, Li; Lu, Sixia; Rong, Nianhe; Liu, Yue; Fang, Jiliang; Shi, Jiaheng; Yang, Wei; Zhao, Bin; Yang, Yang; Zhao, Yufeng; Li, Shaoyuan; Fan, Tiebing; Rong, Peijing; Huang, Luqi.
  • Wang Y; China Academy of Chinese Medical Sciences, Beijing, China.
  • Lu C; China Academy of Chinese Medical Sciences, Beijing, China.
  • Li H; China Academy of Chinese Medical Sciences, Beijing, China.
  • Qi W; China Academy of Chinese Medical Sciences, Beijing, China.
  • Ruan L; Wuhan Jinyintan Hospital, Wuhan, China.
  • Bian Y; China Academy of Chinese Medical Sciences, Beijing, China.
  • Shi H; China Academy of Chinese Medical Sciences, Beijing, China.
  • Song H; Wuhan Jinyintan Hospital, Wuhan, China.
  • Tu S; Wuhan Jinyintan Hospital, Wuhan, China.
  • Zhang Y; Wuhan Jinyintan Hospital, Wuhan, China.
  • Bai T; Wuhan Jinyintan Hospital, Wuhan, China.
  • Cao R; Wuhan Jinyintan Hospital, Wuhan, China.
  • Hong K; Wuhan Jinyintan Hospital, Wuhan, China.
  • Li H; Wuhan Jinyintan Hospital, Wuhan, China.
  • Liu L; Wuhan Jinyintan Hospital, Wuhan, China.
  • Lu S; Wuhan Jinyintan Hospital, Wuhan, China.
  • Rong N; China Academy of Chinese Medical Sciences, Beijing, China.
  • Liu Y; China Academy of Chinese Medical Sciences, Beijing, China.
  • Fang J; China Academy of Chinese Medical Sciences, Beijing, China.
  • Shi J; China Academy of Chinese Medical Sciences, Beijing, China.
  • Yang W; China Academy of Chinese Medical Sciences, Beijing, China.
  • Zhao B; China Academy of Chinese Medical Sciences, Beijing, China.
  • Yang Y; China Academy of Chinese Medical Sciences, Beijing, China.
  • Zhao Y; China Academy of Chinese Medical Sciences, Beijing, China.
  • Li S; China Academy of Chinese Medical Sciences, Beijing, China.
  • Fan T; China Academy of Chinese Medical Sciences, Beijing, China.
  • Rong P; China Academy of Chinese Medical Sciences, Beijing, China.
  • Huang L; China Academy of Chinese Medical Sciences, Beijing, China. Electronic address: huanglq@cacms.cn.
J Ethnopharmacol ; 277: 113888, 2021 Sep 15.
Article in English | MEDLINE | ID: covidwho-1056890
Semantic information from SemMedBD (by NLM)
1. COVID-19 PROCESS_OF Patients
Subject
COVID-19
Predicate
PROCESS_OF
Object
Patients
2. Hospitals LOCATION_OF Retrospective Studies
Subject
Hospitals
Predicate
LOCATION_OF
Object
Retrospective Studies
3. NCKIPSD gene|NCKIPSD PART_OF Patients
Subject
NCKIPSD gene|NCKIPSD
Predicate
PART_OF
Object
Patients
4. Toxin AFFECTS Lung
Subject
Toxin
Predicate
AFFECTS
Object
Lung
5. Intravenous Immunoglobulin TREATS C0012634
Subject
Intravenous Immunoglobulin
Predicate
TREATS
Object
C0012634
6. Invasive mechanical ventilation NOS COEXISTS_WITH Hospitalization
Subject
Invasive mechanical ventilation NOS
Predicate
COEXISTS_WITH
Object
Hospitalization
7. tomography DIAGNOSES Pulmonary opacity
Subject
tomography
Predicate
DIAGNOSES
Object
Pulmonary opacity
8. Serum LOCATION_OF Ferritin
Subject
Serum
Predicate
LOCATION_OF
Object
Ferritin
9. Inflammation AFFECTS Patients
Subject
Inflammation
Predicate
AFFECTS
Object
Patients
10. Hospitals LOCATION_OF Analysis
Subject
Hospitals
Predicate
LOCATION_OF
Object
Analysis
11. COVID-19 PROCESS_OF Patients
Subject
COVID-19
Predicate
PROCESS_OF
Object
Patients
12. Hospitals LOCATION_OF Retrospective Studies
Subject
Hospitals
Predicate
LOCATION_OF
Object
Retrospective Studies
13. NCKIPSD gene|NCKIPSD PART_OF Patients
Subject
NCKIPSD gene|NCKIPSD
Predicate
PART_OF
Object
Patients
14. Toxin AFFECTS Lung
Subject
Toxin
Predicate
AFFECTS
Object
Lung
15. Intravenous Immunoglobulins, Human TREATS Disease
Subject
Intravenous Immunoglobulins, Human
Predicate
TREATS
Object
Disease
16. Invasive mechanical ventilation NOS COEXISTS_WITH Hospitalization
Subject
Invasive mechanical ventilation NOS
Predicate
COEXISTS_WITH
Object
Hospitalization
17. tomography DIAGNOSES Pulmonary opacity
Subject
tomography
Predicate
DIAGNOSES
Object
Pulmonary opacity
18. Serum LOCATION_OF Ferritin
Subject
Serum
Predicate
LOCATION_OF
Object
Ferritin
19. Inflammation AFFECTS Patients
Subject
Inflammation
Predicate
AFFECTS
Object
Patients
20. Hospitals LOCATION_OF Analysis
Subject
Hospitals
Predicate
LOCATION_OF
Object
Analysis
ABSTRACT
ETHNOPHARMACOLOGICAL RELEVANCE The coronavirus disease 2019 (COVID-19) has formed a global pandemic since late 2019. Benefitting from the application experience of Chinese Medicine (CM) for influenza and SARS, CM has been used to save patients at the early stage of COVID-19 outbreak in China. AIM OF THE STUDY In order to evaluate the efficacy and safety of CM, and compare with Western Medicine (WM) for COVID-19, we conducted a retrospective case series study based on the patients in Wuhan Jinyintan Hospital, Wuhan, China.

METHODS:

The inclusion and exclusion criteria of data extraction were set for this retrospective study. All patients who were admitted by the Wuhan Jinyintan Hospital between January 17th and February 25th 2020 were considered. In addition, patients enrolled met the severe defined by the guidelines released by the National Health Commission of the People's Republic of China. In these cases included in the study, CM or WM treatment was selected according to the wishes of the patients at the beginning of hospitalization. The patients in CM group were treated with Huashi Baidu granule (137 g po, bid) combined with the injections of Xiyanping (100 mg iv, bid), Xuebijing (100 ml iv, bid) and Shenmai (60 ml iv, qd) according to the syndrome of epidemic toxin blocking the lung in the theory of Traditional Chinese Medicine. The WM group received antiviral therapy (including abidor capsule 0.2 g po, tid; Lopinavir-Ritonavir tablets, 500 mg po, bid), antibiotics (such as cefoperazone 2 g iv, bid; moxifloxacin hydrochloride tablets, 0.4 g po, qd) or corticosteroid therapy (such as methylprednisolone succinate sodium 40 mg iv, qd; prednisone, 30 mg po, qd). In addition, patients in both groups received routine supportive treatment, including oxygen inhalation, symptomatic therapy, and/or human intravenous immunoglobulin, and/or serum albumin, and treatment for underlying diseases. The clinical outcomes were evaluated based on changes related with clinical manifestations, computer tomography (CT) scan images, and laboratory examinations before and after the treatment.

RESULTS:

55 severe COVID-19 patients, with 23 in CM group and 32 in WM group, were included for analyzed. There was no case of death, being transferred to ICU, or receiving invasive mechanical ventilation in two groups during hospitalization. The median time of SARS-CoV-2 RNA clearance in CM and WM group were 12 days and 15.5 days respectively, the ratio of nucleic acid negative conversion of CM group at different follow-up time points was significantly higher than that of WM group (HR 2.281, P = 0.018). Further, the chest CT imaging showed more widely lung lesion opacity absorbed in the CM group. The high sensitivity C-reactive protein and serum ferritin decreased significantly in the CM group (P<0.05). There was no significant difference in adverse events in terms of liver function and renal function between the two groups.

CONCLUSION:

Based on this retrospective analysis from Wuhan Jinyintan Hospital, CM has better effects in SARS-CoV-2 RNA clearance, promoting lung lesion opacity absorbed and reducing inflammation in severe COVID-19 patients, which is effective and safe therapy for treating severe COVID-19 and reducing mortality.
Subject(s)
Keywords

Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 / Medicine, Chinese Traditional Type of study: Diagnostic study / Clinical Practice Guide / Observational study / Randomized controlled trials / Reviews Topics: Long Covid / Traditional medicine Limits: Adult / Aged / Female / Humans / Male / Middle aged Country/Region as subject: Asia Language: English Journal: J Ethnopharmacol Year: 2021 Document Type: Article Affiliation country: J.jep.2021.113888

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Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 / Medicine, Chinese Traditional Type of study: Diagnostic study / Clinical Practice Guide / Observational study / Randomized controlled trials / Reviews Topics: Long Covid / Traditional medicine Limits: Adult / Aged / Female / Humans / Male / Middle aged Country/Region as subject: Asia Language: English Journal: J Ethnopharmacol Year: 2021 Document Type: Article Affiliation country: J.jep.2021.113888