Regeneration Profiles of Olfactory Epithelium after SARS-CoV-2 Infection in Golden Syrian Hamsters.
ACS Chem Neurosci
; 12(4): 589-595, 2021 02 17.
Article
in English
| MEDLINE | ID: covidwho-1057681
ABSTRACT
Olfactory dysfunction is one of the most frequent and specific symptoms of coronavirus disease 2019 (COVID-19). Information on the damage and repair of the neuroepithelium and its impact on olfactory function after COVID-19 is still incomplete. While severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) causes the ongoing worldwide outbreak of COVID-19, little is known about the changes triggered by SARS-CoV-2 in the olfactory epithelium (OE) at the cellular level. Here, we report profiles of the OE after SARS-CoV-2 infection in golden Syrian hamsters, which is a reliable animal model of COVID-19. We observed severe damage in the OE as early as 3 days postinoculation and regionally specific damage and regeneration of the OE within the nasal cavity; the nasal septal region demonstrated the fastest recovery compared to other regions in the nasal turbinates. These findings suggest that anosmia related to SARS-CoV-2 infection may be fully reversible.
Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Regeneration
/
Olfactory Mucosa
/
Olfactory Receptor Neurons
/
SARS-CoV-2
/
Anosmia
/
COVID-19
Topics:
Long Covid
Limits:
Animals
Language:
English
Journal:
ACS Chem Neurosci
Year:
2021
Document Type:
Article
Affiliation country:
Acschemneuro.0c00649
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