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HIV-1 Infection Does Not Change Disease Course or Inflammatory Pattern of SARS-CoV-2-Infected Patients Presenting at a Large Urban Medical Center in New York City.
Laracy, Justin; Zucker, Jason; Castor, Delivette; McMahon, Donald J; Guo, Tai Wei; Yan, Michael; Shalev, Noga; Scherer, Matthew; Gordon, Peter; Sobieszczyk, Magdalena; Yin, Michael T.
  • Laracy J; NewYork-Presbyterian Hospital/Columbia University Irving Medical Center, New York, New York, USA.
  • Zucker J; ICAP at Columbia University, Mailman School of Public Health, Columbia University, New York, New York, USA.
  • Castor D; Department of Medicine, Division of Infectious Diseases, Columbia University Irving Medical Center, New York, New York, USA.
  • McMahon DJ; Department of Medicine, Division of Infectious Diseases, Columbia University Irving Medical Center, New York, New York, USA.
  • Guo TW; Department of Medicine, Division of Endocrinology, Columbia University Irving Medical Center, New York, New York, USA.
  • Yan M; Columbia University Vagelos College of Physicians and Surgeons, New York, New York, USA.
  • Shalev N; Department of Biostatistics, Columbia University Mailman School of Public Health, New York, New York, USA.
  • Scherer M; Department of Medicine, Division of Infectious Diseases, Columbia University Irving Medical Center, New York, New York, USA.
  • Gordon P; Department of Medicine, Division of Infectious Diseases, Columbia University Irving Medical Center, New York, New York, USA.
  • Sobieszczyk M; Department of Medicine, Division of Infectious Diseases, Columbia University Irving Medical Center, New York, New York, USA.
  • Yin MT; Department of Medicine, Division of Infectious Diseases, Columbia University Irving Medical Center, New York, New York, USA.
Open Forum Infect Dis ; 8(2): ofab029, 2021 Feb.
Article in English | MEDLINE | ID: covidwho-1057869
ABSTRACT

BACKGROUND:

The clinical impact of coronavirus disease 2019 (COVID-19) among people with HIV (PWH) remains unclear. In this retrospective cohort study of COVID-19, we compared clinical outcomes and laboratory parameters among PWH and controls.

METHODS:

Sixty-eight PWH diagnosed with COVID-19 were matched 14 to patients without known HIV diagnosis, drawn from a study population of all patients who were diagnosed with COVID-19 at an academic urban hospital. The primary outcome was death/discharge to hospice within 30 days of hospital presentation.

RESULTS:

PWH were more likely to be admitted from the emergency department than patients without HIV (91% vs 71%; P = .001). We observed no statistically significant difference between admitted PWH and patients without HIV in terms of 30-day mortality rate (19% vs 13%, respectively) or mechanical ventilation rate (18% vs 20%, respectively). PWH had higher erythrocyte sedimentation rates than controls on admission but did not differ in other inflammatory marker levels or nasopharyngeal/oropharyngeal severe acute respiratory syndrome coronavirus 2 viral load estimated by reverse transcriptase polymerase chain reaction cycle thresholds.

CONCLUSIONS:

HIV infection status was associated with a higher admission rate; however, among hospitalized patients, PWH did not differ from HIV-uninfected controls by rate of mechanical ventilation or death/discharge to hospice.
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Full text: Available Collection: International databases Database: MEDLINE Type of study: Cohort study / Observational study / Prognostic study Language: English Journal: Open Forum Infect Dis Year: 2021 Document Type: Article Affiliation country: Ofid

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Full text: Available Collection: International databases Database: MEDLINE Type of study: Cohort study / Observational study / Prognostic study Language: English Journal: Open Forum Infect Dis Year: 2021 Document Type: Article Affiliation country: Ofid