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Type 2 Immunity and Age Modify Gene Expression of Coronavirus-induced Disease 2019 Receptors in Eosinophilic Gastrointestinal Disorders.
Chiang, Austin W T; Duong, Loan D; Shoda, Tetsuo; Nhu, Quan M; Ruffner, Melanie; Hara, Takeo; Aaron, Bailey; Joplin, Erik; Manresa, Mario C; Abonia, J Pablo; Dellon, Evan S; Hirano, Ikuo; Gonsalves, Nirmala; Gupta, Sandeep K; Furuta, Glenn T; Rothenberg, Marc E; Lewis, Nathan E; Muir, Amanda B; Aceves, Seema S.
  • Chiang AWT; Department of Bioengineering.
  • Duong LD; Department of Pediatrics, University of California.
  • Shoda T; Division of Allergy, Immunology, Department of Pediatrics, University of California, San Diego, Rady Children's Hospital, San Diego, CA.
  • Nhu QM; Division of Allergy, Immunology, Department of Pediatrics, Cincinnati Children's Hospital Medical Center, University of Cincinnati, Cincinnati, OH.
  • Ruffner M; Department of Bioengineering.
  • Hara T; Division of Gastroenterology and Hepatology, Scripps Clinic, San Diego, CA.
  • Aaron B; Center for Esophageal Diseases and Swallowing, Division of Gastroenterology and Hepatology, University of North Carolina School of Medicine, Chapel Hill, NC.
  • Joplin E; Department of Pediatrics, Division of Gastroenterology, Children's Hospital of Philadelphia, Philadelphia, PA.
  • Manresa MC; Department of Pediatrics, Division of Gastroenterology, Children's Hospital of Philadelphia, Philadelphia, PA.
  • Abonia JP; Division of Allergy, Immunology, Department of Pediatrics, University of California, San Diego, Rady Children's Hospital, San Diego, CA.
  • Dellon ES; Department of Bioengineering.
  • Hirano I; Division of Allergy, Immunology, Department of Pediatrics, Cincinnati Children's Hospital Medical Center, University of Cincinnati, Cincinnati, OH.
  • Gonsalves N; Center for Esophageal Diseases and Swallowing, Division of Gastroenterology and Hepatology, University of North Carolina School of Medicine, Chapel Hill, NC.
  • Gupta SK; Division of Gastroenterology, Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL.
  • Furuta GT; Division of Gastroenterology, Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL.
  • Rothenberg ME; Division of Gastroenterology, Indiana University School of Medicine, Riley Hospital for Children, Indianapolis, IN.
  • Lewis NE; Digestive Health Institute, Section of Pediatric Gastroenterology, Hepatology and Nutrition, Children's Hospital Colorado, Gastrointestinal Eosinophilic Disease Program, Mucosal Inflammation Program, University of Colorado School of Medicine, Aurora, CO.
  • Muir AB; Division of Allergy, Immunology, Department of Pediatrics, Cincinnati Children's Hospital Medical Center, University of Cincinnati, Cincinnati, OH.
  • Aceves SS; Division of Allergy, Immunology, Department of Pediatrics, University of California, San Diego, Rady Children's Hospital, San Diego, CA.
J Pediatr Gastroenterol Nutr ; 72(5): 718-722, 2021 05 01.
Article in English | MEDLINE | ID: covidwho-1180675
ABSTRACT
ABSTRACT Infection with severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) can lead to coronavirus-induced disease 2019 (COVID-19). The gastrointestinal (GI) tract is now an appreciated portal of infection. SARS-CoV-2 enters host cells via angiotensin-converting enzyme-2 (ACE2) and the serine protease TMPRSS2. Eosinophilic gastrointestinal disorders (EGIDs) are inflammatory conditions caused by chronic type 2 (T2) inflammation. the effects of the T2 atopic inflammatory milieu on SARS-COV-2 viral entry gene expression in the GI tract is poorly understood. We analyzed tissue ACE2 and TMPRSS2 gene expression in pediatric eosinophilic esophagitis (EoE), eosinophilic gastritis (EG), and in normal adult esophagi using publicly available RNA-sequencing datasets. Similar to findings evaluating the airway, there was no difference in tissue ACE2/TMPRSS2 expression in EoE or EG when compared with control non-EoE/EG esophagus/stomach. ACE2 gene expression was significantly lower in esophagi from children with or without EoE and from adults with EoE as compared with normal adult esophagi. Type 2 immunity and pediatric age could be protective for infection by SARS-CoV-2 in the gastrointestinal tract because of decreased expression of ACE2.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Enteritis / COVID-19 Type of study: Experimental Studies Limits: Adult / Child / Humans Language: English Journal: J Pediatr Gastroenterol Nutr Year: 2021 Document Type: Article

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Enteritis / COVID-19 Type of study: Experimental Studies Limits: Adult / Child / Humans Language: English Journal: J Pediatr Gastroenterol Nutr Year: 2021 Document Type: Article