Cytokine Storm and Mucus Hypersecretion in COVID-19: Review of Mechanisms.
J Inflamm Res
; 14: 175-189, 2021.
Article
in English
| MEDLINE | ID: covidwho-1058337
ABSTRACT
Mucus is an integral part of the respiratory physiology. It protects the respiratory tract by acting as a physical barrier against inhaled particles and microbes. Excessive inflammation in conditions such as COVID-19 can result in over-production of mucus which obstructs the airway. Build-up of mucus can also contribute to recurrent airway infection, causing further obstruction. This article summarizes the current understanding and knowledge of respiratory mucus production and proposes the role of cytokine storm in inducing sudden mucus hypersecretion in COVID-19. Based on these cascades, the active constituents that inhibit or activate several potential targets are outlined for further research. These may be explored for the discovery and design of drugs to combat cytokine storm and its ensuing complications.
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Language:
English
Journal:
J Inflamm Res
Year:
2021
Document Type:
Article
Affiliation country:
JIR.S271292
Similar
MEDLINE
...
LILACS
LIS