Can erythrocytes behavior in microcirculation help the understanding the physiopathology and improve prevention and treatment for covid-19?
Clin Hemorheol Microcirc
; 78(1): 41-47, 2021.
Article
in English
| MEDLINE | ID: covidwho-1058391
ABSTRACT
Low plasma estrogens, vitamin D deficiency, obesity, diabetes, cardiovascular diseases, thromboembolism, and impaired microcirculation are linked to the severity of covid-19. Studies have suggested that these comorbidities also are related to erythrocyte factors linked to increased blood viscosity in microcirculation such as erythrocyte aggregation and erythrocyte deformability. Increased blood viscosity in microcirculation can lead to a decrease in oxygenation and nutrition of tissues. Therefore erythrocyte aggregation and erythrocyte deformability may be involved in covid-19 severity, leading to tissue hypoxia and a decrease of drug concentration in affected organs. If this relationship is demonstrated, erythrocytes factors can be used to monitor treatments for improve microcirculatory fluidity that may decrease covid-19 severity. Lifestyle improvement and treatments such as vitamin D and estrogens supplementation are some possible approaches to improve microcirculation and covid-19 prevention and treatment.
Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Erythrocytes
/
COVID-19
/
Microcirculation
Type of study:
Prognostic study
Limits:
Humans
Language:
English
Journal:
Clin Hemorheol Microcirc
Journal subject:
Vascular Diseases
/
Hematology
Year:
2021
Document Type:
Article
Affiliation country:
CH-201082
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