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Adenosine at the Interphase of Hypoxia and Inflammation in Lung Injury.
Li, Xiangyun; Berg, Nathanial K; Mills, Tingting; Zhang, Kaiying; Eltzschig, Holger K; Yuan, Xiaoyi.
  • Li X; Department of Anesthesiology, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, TX, United States.
  • Berg NK; Department of Anesthesiology, Tianjin Medical University NanKai Hospital, Tianjin, China.
  • Mills T; Department of Anesthesiology, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, TX, United States.
  • Zhang K; Department of Biochemistry, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, TX, United States.
  • Eltzschig HK; Department of Anesthesiology, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, TX, United States.
  • Yuan X; Department of Anesthesiology, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, TX, United States.
Front Immunol ; 11: 604944, 2020.
Article in English | MEDLINE | ID: covidwho-1058416
ABSTRACT
Hypoxia and inflammation often coincide in pathogenic conditions such as acute respiratory distress syndrome (ARDS) and chronic lung diseases, which are significant contributors to morbidity and mortality for the general population. For example, the recent global outbreak of Coronavirus disease 2019 (COVID-19) has placed viral infection-induced ARDS under the spotlight. Moreover, chronic lung disease ranks the third leading cause of death in the United States. Hypoxia signaling plays a diverse role in both acute and chronic lung inflammation, which could partially be explained by the divergent function of downstream target pathways such as adenosine signaling. Particularly, hypoxia signaling activates adenosine signaling to inhibit the inflammatory response in ARDS, while in chronic lung diseases, it promotes inflammation and tissue injury. In this review, we discuss the role of adenosine at the interphase of hypoxia and inflammation in ARDS and chronic lung diseases, as well as the current strategy for therapeutic targeting of the adenosine signaling pathway.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Adenosine / Inflammation / Hypoxia Limits: Humans Language: English Journal: Front Immunol Year: 2020 Document Type: Article Affiliation country: Fimmu.2020.604944

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Adenosine / Inflammation / Hypoxia Limits: Humans Language: English Journal: Front Immunol Year: 2020 Document Type: Article Affiliation country: Fimmu.2020.604944