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Neurological manifestations of coronavirus infections: role of angiotensin-converting enzyme 2 in COVID-19.
Parsamanesh, Negin; Pezeshgi, Aiyoub; Hemmati, Mina; Jameshorani, Maryam; Saboory, Ehsan.
  • Parsamanesh N; Zanjan Metabolic Diseases Research Center, Zanjan University of Medical Sciences, Zanjan, Iran.
  • Pezeshgi A; Zanjan Metabolic Diseases Research Center, Zanjan University of Medical Sciences, Zanjan, Iran.
  • Hemmati M; Internal Medicine Department, Zanjan University of Medical Sciences, Zanjan, Iran.
  • Jameshorani M; Faculty of Medicine, Biochemistry Department, Zanjan University of Medical Sciences, Zanjan, Iran.
  • Saboory E; Zanjan Metabolic Diseases Research Center, Zanjan University of Medical Sciences, Zanjan, Iran.
Int J Neurosci ; 132(9): 917-924, 2022 Sep.
Article in English | MEDLINE | ID: covidwho-1059433
ABSTRACT
AIM OF THE STUDY In December 2019, a highly pathogenic coronavirus called SARS-CoV-2 (formerly identified as 2019-nCoV) appeared in Wuhan, China, and has since been spreading rapidly around the world. we reviewed the neurological manifestations of this infection and the potential of ACE2 in the nervous system. MATERIALS AND

METHODS:

Six databases (Medline, Scopus, Embase, Web of Science, WHO, and google scholar) were searched and screened by the authors for having appropriate information about covid-19. Finally, 72 studies were identified, summarized and reviewed.

RESULT:

The most specific manifestation of SARS-CoV-2 patients is pulmonary distress, and several patients admitted to intensive care units were not able to breathe spontaneously. In addition, the SARS-CoV-2 outbreak has a significant effect on nervous systems and may even lead to serious neurological damage. The neuroinvasive pathobiology is still not fully elucidated and thus the effect of CoV infections on the nervous system needs to be explored. The spike protein of the virus and the angiotensin-converting enzyme 2 (ACE2) lead to the presence of both SARS-CoV and SARS-CoV-2 in the cells and, subsequently, decreased ACE2 expression.

CONCLUSION:

The therapeutic possibilities of ACE2 antibody, ACE2-derived peptides, and small molecule blockers of ACE2 include a receptor-binding domain blocking approach. Hence, future studies of ACE2 may be very helpful in discovering a therapy for SARS-CoV-2.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Severe acute respiratory syndrome-related coronavirus / COVID-19 Type of study: Reviews Topics: Long Covid Limits: Humans Language: English Journal: Int J Neurosci Year: 2022 Document Type: Article Affiliation country: 00207454.2020.1849193

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Severe acute respiratory syndrome-related coronavirus / COVID-19 Type of study: Reviews Topics: Long Covid Limits: Humans Language: English Journal: Int J Neurosci Year: 2022 Document Type: Article Affiliation country: 00207454.2020.1849193