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The Association between Presence of Comorbidities and COVID-19 Severity: A Systematic Review and Meta-Analysis.
Honardoost, Maryam; Janani, Laila; Aghili, Rokhsareh; Emami, Zahra; Khamseh, Mohammad E.
  • Honardoost M; Endocrine Research Center, Institute of Endocrinology and Metabolism, Iran University of Medical Sciences, Tehran, Iran.
  • Janani L; Cardio-Oncology Research Center, Rajaie Cardiovascular Medical & Research Center, Iran University of Medical Sciences, Tehran, Iran.
  • Aghili R; Biostatistics Department, School of Public Health, Iran University of Medical Sciences, Tehran, Iran.
  • Emami Z; Endocrine Research Center, Institute of Endocrinology and Metabolism, Iran University of Medical Sciences, Tehran, Iran.
  • Khamseh ME; Endocrine Research Center, Institute of Endocrinology and Metabolism, Iran University of Medical Sciences, Tehran, Iran.
Cerebrovasc Dis ; 50(2): 132-140, 2021.
Article in English | MEDLINE | ID: covidwho-1059436
ABSTRACT

AIM:

Several studies reported the accompaniment of severe COVID-19 with comorbidities. However, there is not a systematic evaluation of all aspects of this association. Therefore, this meta-analysis aimed to assess the association between all underlying comorbidities in COVID-19 infection severity.

METHODS:

Electronic literature search was performed via scientific search engines. After the removal of duplicates and selection of articles of interest, 28 studies were included. A fixed-effects model was used; however, if heterogeneity was high (I2 > 50%) a random-effects model was applied to combine the data.

RESULTS:

A total of 6,270 individuals were assessed (1,615 severe and 4,655 non-severe patients). The median age was 63 (95% confidence interval [CI] 49-74) and 47 (95% CI 19-63) years in the severe and non-severe groups, respectively. Moreover, about 41% of patients had comorbidities. Severity was higher in patients with a history of cerebrovascular disease OR 4.85 (95% CI 3.11-7.57). The odds of being in a severe group increase by 4.81 (95% CI 3.43-6.74) for a history of cardiovascular disease (CVD). This was 4.19 (95% CI 2.84-6.19) for chronic lung disease and 3.18, 95% CI 2.09-4.82 for cancer. The odds ratios of diabetes and hypertension were 2.61 (95% CI 2.02-3.3) and 2.37 (95% CI 1.80-3.13), respectively.

CONCLUSIONS:

The presence of comorbidities is associated with severity of COVID-19 infection. The strongest association was observed for cerebrovascular disease, followed by CVD, chronic lung disease, cancer, diabetes, and hypertension.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Cardiovascular Diseases / Cerebrovascular Disorders / Diabetes Mellitus / SARS-CoV-2 / COVID-19 Type of study: Experimental Studies / Observational study / Prognostic study / Randomized controlled trials / Reviews / Systematic review/Meta Analysis Topics: Long Covid Limits: Humans Language: English Journal: Cerebrovasc Dis Journal subject: Vascular Diseases / Brain Year: 2021 Document Type: Article Affiliation country: 000513288

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Cardiovascular Diseases / Cerebrovascular Disorders / Diabetes Mellitus / SARS-CoV-2 / COVID-19 Type of study: Experimental Studies / Observational study / Prognostic study / Randomized controlled trials / Reviews / Systematic review/Meta Analysis Topics: Long Covid Limits: Humans Language: English Journal: Cerebrovasc Dis Journal subject: Vascular Diseases / Brain Year: 2021 Document Type: Article Affiliation country: 000513288