Development of a coronavirus disease 2019 nonhuman primate model using airborne exposure.
PLoS One
; 16(2): e0246366, 2021.
Article
in English
| MEDLINE | ID: covidwho-1059447
ABSTRACT
Airborne transmission is predicted to be a prevalent route of human exposure with SARS-CoV-2. Aside from African green monkeys, nonhuman primate models that replicate airborne transmission of SARS-CoV-2 have not been investigated. A comparative evaluation of COVID-19 in African green monkeys, rhesus macaques, and cynomolgus macaques following airborne exposure to SARS-CoV-2 was performed to determine critical disease parameters associated with disease progression, and establish correlations between primate and human COVID-19. Respiratory abnormalities and viral shedding were noted for all animals, indicating successful infection. Cynomolgus macaques developed fever, and thrombocytopenia was measured for African green monkeys and rhesus macaques. Type II pneumocyte hyperplasia and alveolar fibrosis were more frequently observed in lung tissue from cynomolgus macaques and African green monkeys. The data indicate that, in addition to African green monkeys, macaques can be successfully infected by airborne SARS-CoV-2, providing viable macaque natural transmission models for medical countermeasure evaluation.
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Disease Models, Animal
/
SARS-CoV-2
/
COVID-19
/
Macaca mulatta
Type of study:
Experimental Studies
/
Prognostic study
Limits:
Animals
Language:
English
Journal:
PLoS One
Journal subject:
Science
/
Medicine
Year:
2021
Document Type:
Article
Affiliation country:
Journal.pone.0246366
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