The interplay between neutrophils, complement, and microthrombi in COVID-19.
Best Pract Res Clin Rheumatol
; 35(1): 101661, 2021 03.
Article
in English
| MEDLINE | ID: covidwho-1059489
ABSTRACT
As of the end of 2020, coronavirus disease 2019 (COVID-19) remains a global healthcare challenge with alarming death tolls. In the absence of targeted therapies, supportive care continues to be the mainstay of treatment. The hallmark of severe COVID-19 is a thromboinflammatory storm driven by innate immune responses. This manifests clinically as acute respiratory distress syndrome, and in some patients, widespread thrombotic microangiopathy. Neutrophils and complement are key players in the innate immune system, and their role in perpetuating fatal severe COVID-19 continues to receive increasing attention. Here, we review the interplay between neutrophils, neutrophil extracellular traps, and complement in COVID-19 immunopathology, and highlight potential therapeutic strategies to combat these pathways.
Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Respiratory Distress Syndrome
/
Extracellular Traps
/
COVID-19
Type of study:
Prognostic study
Limits:
Humans
Language:
English
Journal:
Best Pract Res Clin Rheumatol
Journal subject:
Rheumatology
Year:
2021
Document Type:
Article
Affiliation country:
J.berh.2021.101661
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