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Cardiovascular risk factors and mortality in hospitalized patients with COVID-19: systematic review and meta-analysis of 45 studies and 18,300 patients.
Silverio, Angelo; Di Maio, Marco; Citro, Rodolfo; Esposito, Luca; Iuliano, Giuseppe; Bellino, Michele; Baldi, Cesare; De Luca, Giuseppe; Ciccarelli, Michele; Vecchione, Carmine; Galasso, Gennaro.
  • Silverio A; Department of Medicine, Surgery and Dentistry, University of Salerno, Baronissi, Salerno, Italy.
  • Di Maio M; Department of Medicine, Surgery and Dentistry, University of Salerno, Baronissi, Salerno, Italy.
  • Citro R; Division of Cardiology, Cardiovascular and Thoracic Department, University Hospital ''San Giovanni di Dio e Ruggi d'Aragona'', Salerno, Italy.
  • Esposito L; Division of Cardiology, Cardiovascular and Thoracic Department, University Hospital ''San Giovanni di Dio e Ruggi d'Aragona'', Salerno, Italy.
  • Iuliano G; Division of Cardiology, Cardiovascular and Thoracic Department, University Hospital ''San Giovanni di Dio e Ruggi d'Aragona'', Salerno, Italy.
  • Bellino M; Division of Cardiology, Cardiovascular and Thoracic Department, University Hospital ''San Giovanni di Dio e Ruggi d'Aragona'', Salerno, Italy.
  • Baldi C; Division of Cardiology, Cardiovascular and Thoracic Department, University Hospital ''San Giovanni di Dio e Ruggi d'Aragona'', Salerno, Italy.
  • De Luca G; Division of Cardiology, Azienda Ospedaliera-Universitaria ''Maggiore della Carità'', Eastern Piedmont University, Novara, Italy.
  • Ciccarelli M; Department of Medicine, Surgery and Dentistry, University of Salerno, Baronissi, Salerno, Italy.
  • Vecchione C; Department of Medicine, Surgery and Dentistry, University of Salerno, Baronissi, Salerno, Italy.
  • Galasso G; Vascular Pathophysiology Unit, IRCCS Neuromed, Pozzilli, Isernia, Italy.
BMC Cardiovasc Disord ; 21(1): 23, 2021 01 07.
Article in English | MEDLINE | ID: covidwho-1059712
Semantic information from SemMedBD (by NLM)
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ABSTRACT

BACKGROUND:

A high prevalence of cardiovascular risk factors including age, male sex, hypertension, diabetes, and tobacco use, has been reported in patients with Coronavirus disease 2019 (COVID-19) who experienced adverse outcome. The aim of this study was to investigate the relationship between cardiovascular risk factors and in-hospital mortality in patients with COVID-19.

METHODS:

MEDLINE, Cochrane, Web of Sciences, and SCOPUS were searched for retrospective or prospective observational studies reporting data on cardiovascular risk factors and in-hospital mortality in patients with COVID-19. Univariable and multivariable age-adjusted analyses were conducted to evaluate the association between cardiovascular risk factors and the occurrence of in-hospital death.

RESULTS:

The analysis included 45 studies enrolling 18,300 patients. The pooled estimate of in-hospital mortality was 12% (95% CI 9-15%). The univariable meta-regression analysis showed a significant association between age (coefficient 1.06; 95% CI 1.04-1.09; p < 0.001), diabetes (coefficient 1.04; 95% CI 1.02-1.07; p < 0.001) and hypertension (coefficient 1.01; 95% CI 1.01-1.03; p = 0.013) with in-hospital death. Male sex and smoking did not significantly affect mortality. At multivariable age-adjusted meta-regression analysis, diabetes was significantly associated with in-hospital mortality (coefficient 1.02; 95% CI 1.01-1.05; p = 0.043); conversely, hypertension was no longer significant after adjustment for age (coefficient 1.00; 95% CI 0.99-1.01; p = 0.820). A significant association between age and in-hospital mortality was confirmed in all multivariable models.

CONCLUSIONS:

This meta-analysis suggests that older age and diabetes are associated with higher risk of in-hospital mortality in patients infected by SARS-CoV-2. Conversely, male sex, hypertension, and smoking did not independently correlate with fatal outcome.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Cardiovascular Diseases / Hospital Mortality / SARS-CoV-2 / COVID-19 Type of study: Experimental Studies / Observational study / Prognostic study / Reviews / Systematic review/Meta Analysis Limits: Female / Humans / Male Language: English Journal: BMC Cardiovasc Disord Journal subject: Vascular Diseases / Cardiology Year: 2021 Document Type: Article Affiliation country: S12872-020-01816-3

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Cardiovascular Diseases / Hospital Mortality / SARS-CoV-2 / COVID-19 Type of study: Experimental Studies / Observational study / Prognostic study / Reviews / Systematic review/Meta Analysis Limits: Female / Humans / Male Language: English Journal: BMC Cardiovasc Disord Journal subject: Vascular Diseases / Cardiology Year: 2021 Document Type: Article Affiliation country: S12872-020-01816-3