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Increased interleukin-6 and macrophage chemoattractant protein-1 are associated with respiratory failure in COVID-19.
Jøntvedt Jørgensen, Marthe; Holter, Jan Cato; Christensen, Erik Egeland; Schjalm, Camilla; Tonby, Kristian; Pischke, Søren Erik; Jenum, Synne; Skeie, Linda G; Nur, Sarah; Lind, Andreas; Opsand, Hanne; Enersen, Tone Burvald; Grøndahl, Ragnhild; Hermann, Anne; Dudman, Susanne; Muller, Fredrik; Ueland, Thor; Mollnes, Tom Eirik; Aukrust, Pål; Heggelund, Lars; Holten, Aleksander Rygh; Dyrhol-Riise, Anne Ma.
  • Jøntvedt Jørgensen M; Department of Infectious Diseases, Oslo University Hospital, Oslo, Norway.
  • Holter JC; Institute of Clinical Medicine, University of Oslo, Oslo, Norway.
  • Christensen EE; Institute of Clinical Medicine, University of Oslo, Oslo, Norway.
  • Schjalm C; Department of Microbiology, Oslo University Hospital, Oslo, Norway.
  • Tonby K; Department of Infectious Diseases, Oslo University Hospital, Oslo, Norway.
  • Pischke SE; Institute of Clinical Medicine, University of Oslo, Oslo, Norway.
  • Jenum S; Department of Immunology, Oslo University Hospital, Oslo, Norway.
  • Skeie LG; Department of Infectious Diseases, Oslo University Hospital, Oslo, Norway.
  • Nur S; Institute of Clinical Medicine, University of Oslo, Oslo, Norway.
  • Lind A; Department of Immunology, Oslo University Hospital, Oslo, Norway.
  • Opsand H; Division of Emergencies and Critical Care, Oslo University Hospital, Oslo, Norway.
  • Enersen TB; Department of Infectious Diseases, Oslo University Hospital, Oslo, Norway.
  • Grøndahl R; Department of Infectious Diseases, Oslo University Hospital, Oslo, Norway.
  • Hermann A; Department of Infectious Diseases, Oslo University Hospital, Oslo, Norway.
  • Dudman S; Department of Microbiology, Oslo University Hospital, Oslo, Norway.
  • Muller F; Department of Internal Medicine, Drammen Hospital, Vestre Viken Hospital Trust, Drammen, Norway.
  • Ueland T; Department of Rheumatology, Drammen Hospital, Vestre Viken Hospital Trust, Drammen, Norway.
  • Mollnes TE; Department of Laboratory Medicine, Drammen Hospital, Vestre Viken Hospital Trust, Drammen, Norway.
  • Aukrust P; Department of Rheumatology, Drammen Hospital, Vestre Viken Hospital Trust, Drammen, Norway.
  • Heggelund L; Institute of Clinical Medicine, University of Oslo, Oslo, Norway.
  • Holten AR; Department of Microbiology, Oslo University Hospital, Oslo, Norway.
  • Dyrhol-Riise AM; Institute of Clinical Medicine, University of Oslo, Oslo, Norway.
Sci Rep ; 10(1): 21697, 2020 12 10.
Article in English | MEDLINE | ID: covidwho-1059940
ABSTRACT
In SARS-CoV-2 infection there is an urgent need to identify patients that will progress to severe COVID-19 and may benefit from targeted treatment. In this study we analyzed plasma cytokines in COVID-19 patients and investigated their association with respiratory failure (RF) and treatment in Intensive Care Unit (ICU). Hospitalized patients (n = 34) with confirmed COVID-19 were recruited into a prospective cohort study. Clinical data and blood samples were collected at inclusion and after 2-5 and 7-10 days. RF was defined as PaO2/FiO2 ratio (P/F) < 40 kPa. Plasma cytokines were analyzed by a Human Cytokine 27-plex assay. COVID-19 patients with RF and/or treated in ICU showed overall increased systemic cytokine levels. Plasma IL-6, IL-8, G-CSF, MCP-1, MIP-1α levels were negatively correlated with P/F, whereas combinations of IL-6, IP-10, IL-1ra and MCP-1 showed the best association with RF in ROC analysis (AUC 0.79-0.80, p < 0.05). During hospitalization the decline was most significant for IP-10 (p < 0.001). Elevated levels of pro-inflammatory cytokines were present in patients with severe COVID-19. IL-6 and MCP-1 were inversely correlated with P/F with the largest AUC in ROC analyses and should be further explored as biomarkers to identify patients at risk for severe RF and as targets for improved treatment strategies.
Subject(s)

Full text: Available Collection: International databases Database: MEDLINE Main subject: Respiratory Insufficiency / Interleukin-6 / Chemokine CCL2 / SARS-CoV-2 / COVID-19 Type of study: Cohort study / Observational study / Prognostic study Topics: Long Covid Limits: Adult / Aged / Female / Humans / Male / Middle aged Language: English Journal: Sci Rep Year: 2020 Document Type: Article Affiliation country: S41598-020-78710-7

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Respiratory Insufficiency / Interleukin-6 / Chemokine CCL2 / SARS-CoV-2 / COVID-19 Type of study: Cohort study / Observational study / Prognostic study Topics: Long Covid Limits: Adult / Aged / Female / Humans / Male / Middle aged Language: English Journal: Sci Rep Year: 2020 Document Type: Article Affiliation country: S41598-020-78710-7