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Effects of COVID-19 Home Confinement on Mental Health in Individuals with Increased Risk of Alzheimer's Disease.
Soldevila-Domenech, Natalia; Forcano, Laura; Boronat, Anna; Lorenzo, Thais; Piera, Iris; Puig-Pijoan, Albert; Mateus, Julian; González de Echevarri Gómez, José María; Knezevic, Iva; Soteras, Anna; Fauria, Karine; Pizarro, Nieves; Molinuevo, Jose Luis; de la Torre, Rafael.
  • Soldevila-Domenech N; Integrative Pharmacology and Systems Neurosciences Research Group, Neurosciences Research Program, Hospital del Mar Medical Research Institute (IMIM), Barcelona, Spain.
  • Forcano L; Department of Experimental and Health Sciences, University Pompeu Fabra, Barcelona, Spain.
  • Boronat A; Integrative Pharmacology and Systems Neurosciences Research Group, Neurosciences Research Program, Hospital del Mar Medical Research Institute (IMIM), Barcelona, Spain.
  • Lorenzo T; CIBER de Fisiopatología de la Obesidad y la Nutrición (CIBEROBN), Instituto de Salud Carlos III, Madrid, Spain.
  • Piera I; Integrative Pharmacology and Systems Neurosciences Research Group, Neurosciences Research Program, Hospital del Mar Medical Research Institute (IMIM), Barcelona, Spain.
  • Puig-Pijoan A; Integrative Pharmacology and Systems Neurosciences Research Group, Neurosciences Research Program, Hospital del Mar Medical Research Institute (IMIM), Barcelona, Spain.
  • Mateus J; Department of Experimental and Health Sciences, University Pompeu Fabra, Barcelona, Spain.
  • González de Echevarri Gómez JM; Integrative Pharmacology and Systems Neurosciences Research Group, Neurosciences Research Program, Hospital del Mar Medical Research Institute (IMIM), Barcelona, Spain.
  • Knezevic I; Integrative Pharmacology and Systems Neurosciences Research Group, Neurosciences Research Program, Hospital del Mar Medical Research Institute (IMIM), Barcelona, Spain.
  • Soteras A; Cognitive Impairment and Movement Disorders Unit, Neurology Service, Hospital del Mar, Barcelona, Spain.
  • Fauria K; Integrative Pharmacology and Systems Neurosciences Research Group, Neurosciences Research Program, Hospital del Mar Medical Research Institute (IMIM), Barcelona, Spain.
  • Pizarro N; Barcelonaßeta Brain Research Center (BBRC), Pasqual Maragall Foundation, Barcelona, Spain.
  • Molinuevo JL; Physiology of Cognition and Alzheimer's Prevention Research Group, Neurosciences Research Program, Hospital del Mar Medical Research Institute (IMIM), Barcelona, Spain.
  • de la Torre R; Barcelonaßeta Brain Research Center (BBRC), Pasqual Maragall Foundation, Barcelona, Spain.
J Alzheimers Dis ; 79(3): 1015-1021, 2021.
Article in English | MEDLINE | ID: covidwho-1060642
ABSTRACT
We explored the impact of the Spanish COVID-19 strict home confinement on mental health and cognition in non-infected subjects (N = 16, 60-80 years) diagnosed with subjective cognitive decline and APOEɛ3/ɛ4 carriers. Mental health was monitored for 2 months on a daily, weekly, or monthly basis, and compared to pre-confinement values. Emotional distress, anxiety, and depression scores increased to pathological threshold values during and after confinement. Those with lower mood during confinement experienced a decline in their mood after confinement. Cognition did not change. These preliminary results suggest that mental health consequences of corona measures in preclinical stages of Alzheimer's disease should be further evaluated.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Quarantine / Mental Health / Cognition Disorders / Alzheimer Disease / COVID-19 Type of study: Diagnostic study / Experimental Studies / Prognostic study / Qualitative research Topics: Long Covid Limits: Aged / Female / Humans / Male / Middle aged Country/Region as subject: Europa Language: English Journal: J Alzheimers Dis Journal subject: Geriatrics / Neurology Year: 2021 Document Type: Article Affiliation country: JAD-201408

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Quarantine / Mental Health / Cognition Disorders / Alzheimer Disease / COVID-19 Type of study: Diagnostic study / Experimental Studies / Prognostic study / Qualitative research Topics: Long Covid Limits: Aged / Female / Humans / Male / Middle aged Country/Region as subject: Europa Language: English Journal: J Alzheimers Dis Journal subject: Geriatrics / Neurology Year: 2021 Document Type: Article Affiliation country: JAD-201408