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Mucosal-Associated Invariant T (MAIT) Cells Are Highly Activated and Functionally Impaired in COVID-19 Patients.
Deschler, Sebastian; Kager, Juliane; Erber, Johanna; Fricke, Lisa; Koyumdzhieva, Plamena; Georgieva, Alexandra; Lahmer, Tobias; Wiessner, Johannes R; Voit, Florian; Schneider, Jochen; Horstmann, Julia; Iakoubov, Roman; Treiber, Matthias; Winter, Christof; Ruland, Jürgen; Busch, Dirk H; Knolle, Percy A; Protzer, Ulrike; Spinner, Christoph D; Schmid, Roland M; Quante, Michael; Böttcher, Katrin.
  • Deschler S; Department of Internal Medicine II, University Hospital Rechts der Isar, School of Medicine, Technical University of Munich (TUM), 81675 Munich, Germany.
  • Kager J; Department of Internal Medicine II, University Hospital Rechts der Isar, School of Medicine, Technical University of Munich (TUM), 81675 Munich, Germany.
  • Erber J; Department of Internal Medicine II, University Hospital Rechts der Isar, School of Medicine, Technical University of Munich (TUM), 81675 Munich, Germany.
  • Fricke L; Department of Internal Medicine II, University Hospital Rechts der Isar, School of Medicine, Technical University of Munich (TUM), 81675 Munich, Germany.
  • Koyumdzhieva P; Department of Internal Medicine II, University Hospital Rechts der Isar, School of Medicine, Technical University of Munich (TUM), 81675 Munich, Germany.
  • Georgieva A; Department of Internal Medicine II, University Hospital Rechts der Isar, School of Medicine, Technical University of Munich (TUM), 81675 Munich, Germany.
  • Lahmer T; Department of Internal Medicine II, University Hospital Rechts der Isar, School of Medicine, Technical University of Munich (TUM), 81675 Munich, Germany.
  • Wiessner JR; Department of Internal Medicine II, University Hospital Rechts der Isar, School of Medicine, Technical University of Munich (TUM), 81675 Munich, Germany.
  • Voit F; Department of Internal Medicine II, University Hospital Rechts der Isar, School of Medicine, Technical University of Munich (TUM), 81675 Munich, Germany.
  • Schneider J; Department of Internal Medicine II, University Hospital Rechts der Isar, School of Medicine, Technical University of Munich (TUM), 81675 Munich, Germany.
  • Horstmann J; Department of Internal Medicine II, University Hospital Rechts der Isar, School of Medicine, Technical University of Munich (TUM), 81675 Munich, Germany.
  • Iakoubov R; Department of Internal Medicine II, University Hospital Rechts der Isar, School of Medicine, Technical University of Munich (TUM), 81675 Munich, Germany.
  • Treiber M; Department of Internal Medicine II, University Hospital Rechts der Isar, School of Medicine, Technical University of Munich (TUM), 81675 Munich, Germany.
  • Winter C; Institute of Clinical Chemistry and Pathobiochemistry, School of Medicine, Technical University of Munich, 81675 Munich, Germany.
  • Ruland J; German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany.
  • Busch DH; Institute of Clinical Chemistry and Pathobiochemistry, School of Medicine, Technical University of Munich, 81675 Munich, Germany.
  • Knolle PA; German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany.
  • Protzer U; Institute for Medical Microbiology, Immunology and Hygiene, Technical University of Munich, 81675 Munich, Germany.
  • Spinner CD; Institute of Molecular Immunology and Experimental Oncology, University Hospital Rechts der Isar, Technical University of Munich, 81675 Munich, Germany.
  • Schmid RM; Institute of Virology, Technical University of Munich/Helmholtz Zentrum München, 81675 Munich, Germany.
  • Quante M; German Center for Infection Research (DZIF), 38124 Braunschweig, Partner Site Munich, Germany.
  • Böttcher K; Department of Internal Medicine II, University Hospital Rechts der Isar, School of Medicine, Technical University of Munich (TUM), 81675 Munich, Germany.
Viruses ; 13(2)2021 02 03.
Article in English | MEDLINE | ID: covidwho-1060774
Semantic information from SemMedBD (by NLM)
1. COVID-19 PROCESS_OF Patients
Subject
COVID-19
Predicate
PROCESS_OF
Object
Patients
2. Epidermal cGVHD Score 2 PROCESS_OF Patients
Subject
Epidermal cGVHD Score 2
Predicate
PROCESS_OF
Object
Patients
3. physiological aspects PROCESS_OF Patients
Subject
physiological aspects
Predicate
PROCESS_OF
Object
Patients
4. IL17A protei PART_OF C0079189
Subject
IL17A protei
Predicate
PART_OF
Object
C0079189
5. Anti-Bacterial Agents TREATS COVID-19
Subject
Anti-Bacterial Agents
Predicate
TREATS
Object
COVID-19
6. COVID-19 PROCESS_OF Patients
Subject
COVID-19
Predicate
PROCESS_OF
Object
Patients
7. Epidermal cGVHD Score 2 PROCESS_OF Patients
Subject
Epidermal cGVHD Score 2
Predicate
PROCESS_OF
Object
Patients
8. physiological aspects PROCESS_OF Patients
Subject
physiological aspects
Predicate
PROCESS_OF
Object
Patients
9. IL17A protein, human|IL17A PART_OF cytokine
Subject
IL17A protein, human|IL17A
Predicate
PART_OF
Object
cytokine
10. Anti-Bacterial Agents TREATS COVID-19
Subject
Anti-Bacterial Agents
Predicate
TREATS
Object
COVID-19
ABSTRACT
Coronavirus disease 2019 (COVID-19), caused by infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), comprises mild courses of disease as well as progression to severe disease, characterised by lung and other organ failure. The immune system is considered to play a crucial role for the pathogenesis of COVID-19, although especially the contribution of innate-like T cells remains poorly understood. Here, we analysed the phenotype and function of mucosal-associated invariant T (MAIT) cells, innate-like T cells with potent antimicrobial effector function, in patients with mild and severe COVID-19 by multicolour flow cytometry. Our data indicate that MAIT cells are highly activated in patients with COVID-19, irrespective of the course of disease, and express high levels of proinflammatory cytokines such as IL-17A and TNFα ex vivo. Of note, expression of the activation marker HLA-DR positively correlated with SAPS II score, a measure of disease severity. Upon MAIT cell-specific in vitro stimulation, MAIT cells however failed to upregulate expression of the cytokines IL-17A and TNFα, as well as cytolytic proteins, that is, granzyme B and perforin. Thus, our data point towards an altered cytokine expression profile alongside an impaired antibacterial and antiviral function of MAIT cells in COVID-19 and thereby contribute to the understanding of COVID-19 immunopathogenesis.
Subject(s)
Keywords

Full text: Available Collection: International databases Database: MEDLINE Main subject: Lymphocyte Activation / Mucosal-Associated Invariant T Cells / COVID-19 Type of study: Risk factors Limits: Female / Humans / Male Language: English Year: 2021 Document Type: Article Affiliation country: V13020241

Full text: Available Collection: International databases Database: MEDLINE Main subject: Lymphocyte Activation / Mucosal-Associated Invariant T Cells / COVID-19 Type of study: Risk factors Limits: Female / Humans / Male Language: English Year: 2021 Document Type: Article Affiliation country: V13020241