Mucosal-Associated Invariant T (MAIT) Cells Are Highly Activated and Functionally Impaired in COVID-19 Patients.
Viruses
; 13(2)2021 02 03.
Article
in English
| MEDLINE | ID: covidwho-1060774
Semantic information from SemMedBD (by NLM)
1. COVID-19 PROCESS_OF Patients
2. Epidermal cGVHD Score 2 PROCESS_OF Patients
3. physiological aspects PROCESS_OF Patients
4. IL17A protei PART_OF C0079189
5. Anti-Bacterial Agents TREATS COVID-19
6. COVID-19 PROCESS_OF Patients
7. Epidermal cGVHD Score 2 PROCESS_OF Patients
8. physiological aspects PROCESS_OF Patients
9. IL17A protein, human|IL17A PART_OF cytokine
10. Anti-Bacterial Agents TREATS COVID-19
ABSTRACT
Coronavirus disease 2019 (COVID-19), caused by infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), comprises mild courses of disease as well as progression to severe disease, characterised by lung and other organ failure. The immune system is considered to play a crucial role for the pathogenesis of COVID-19, although especially the contribution of innate-like T cells remains poorly understood. Here, we analysed the phenotype and function of mucosal-associated invariant T (MAIT) cells, innate-like T cells with potent antimicrobial effector function, in patients with mild and severe COVID-19 by multicolour flow cytometry. Our data indicate that MAIT cells are highly activated in patients with COVID-19, irrespective of the course of disease, and express high levels of proinflammatory cytokines such as IL-17A and TNFα ex vivo. Of note, expression of the activation marker HLA-DR positively correlated with SAPS II score, a measure of disease severity. Upon MAIT cell-specific in vitro stimulation, MAIT cells however failed to upregulate expression of the cytokines IL-17A and TNFα, as well as cytolytic proteins, that is, granzyme B and perforin. Thus, our data point towards an altered cytokine expression profile alongside an impaired antibacterial and antiviral function of MAIT cells in COVID-19 and thereby contribute to the understanding of COVID-19 immunopathogenesis.
Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Lymphocyte Activation
/
Mucosal-Associated Invariant T Cells
/
COVID-19
Type of study:
Risk factors
Limits:
Female
/
Humans
/
Male
Language:
English
Year:
2021
Document Type:
Article
Affiliation country:
V13020241