Mediastinal lymphadenopathy may predict 30-day mortality in patients with COVID-19.
Clin Imaging
; 75: 119-124, 2021 Jul.
Article
in English
| MEDLINE | ID: covidwho-1062295
ABSTRACT
PURPOSE:
There is scarce data on the impact of the presence of mediastinal lymphadenopathy on the prognosis of coronavirus-disease 2019 (COVID-19). We aimed to investigate whether its presence is associated with increased risk for 30-day mortality in a large group of patients with COVID-19.METHOD:
In this retrospective cross-sectional study, 650 adult laboratory-confirmed hospitalized COVID-19 patients were included. Patients with comorbidities that may cause enlarged mediastinal lymphadenopathy were excluded. Demographics, clinical characteristics, vital and laboratory findings, and outcome were obtained from electronic medical records. Computed tomography scans were evaluated by two blinded radiologists. Univariate and multivariate logistic regression analyses were performed to determine independent predictive factors of 30-day mortality.RESULTS:
Patients with enlarged mediastinal lymphadenopathy (n = 60, 9.2%) were older and more likely to have at least one comorbidity than patients without enlarged mediastinal lymphadenopathy (p = 0.03, p = 0.003). There were more deaths in patients with enlarged mediastinal lymphadenopathy than in those without (11/60 vs 45/590, p = 0.01). Older age (OR3.74, 95% CI 2.06-6.79; p < 0.001), presence of consolidation pattern (OR1.93, 95% CI 1.09-3.40; p = 0.02) and enlarged mediastinal lymphadenopathy (OR2.38, 95% CI1.13-4.98; p = 0.02) were independently associated with 30-day mortality.CONCLUSION:
In this large group of hospitalized patients with COVID-19, we found that in addition to older age and consolidation pattern on CT scan, enlarged mediastinal lymphadenopathy were independently associated with increased mortality. Mediastinal evaluation should be performed in all patients with COVID-19.Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Lymphadenopathy
/
COVID-19
Type of study:
Experimental Studies
/
Observational study
/
Prognostic study
/
Randomized controlled trials
Limits:
Adult
/
Aged
/
Humans
Language:
English
Journal:
Clin Imaging
Journal subject:
Diagnostic Imaging
Year:
2021
Document Type:
Article
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