Your browser doesn't support javascript.
The Influence of Immune Immaturity on Outcome After Virus Infections.
Shaw, Elana R; Su, Helen C.
  • Shaw ER; Human Immunological Diseases Section, Laboratory of Clinical Immunology and Microbiology, Intramural Research Program, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Md.
  • Su HC; Human Immunological Diseases Section, Laboratory of Clinical Immunology and Microbiology, Intramural Research Program, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Md. Electronic address: hsu@niaid.nih.gov.
J Allergy Clin Immunol Pract ; 9(2): 641-650, 2021 02.
Article in English | MEDLINE | ID: covidwho-1062428
ABSTRACT
Maturation of the adaptive immune response is typically thought to improve outcome to virus infections. However, long-standing observations of natural infections with old viruses such as Epstein-Barr virus and newer observations of emerging viruses such as severe acute respiratory syndrome coronavirus 2 responsible for COVID-19 suggest that immune immaturity may be beneficial for outcome. Mechanistic studies and studies of patients with inborn errors of immunity have revealed that immune dysregulation reflecting inappropriate antibody and T-cell responses plays a crucial role in causing bystander inflammation and more severe disease. Further evidence supports a role for innate immunity in normally regulating adaptive immune responses. Thus, changes in immune responses that normally occur with age may help explain an apparent protective role of immune immaturity during virus infections.
Subject(s)
Keywords

Full text: Available Collection: International databases Database: MEDLINE Main subject: Virus Diseases / Aging Type of study: Observational study / Prognostic study Limits: Animals / Humans Language: English Journal: J Allergy Clin Immunol Pract Year: 2021 Document Type: Article Affiliation country: J.jaip.2020.11.016

Similar

MEDLINE

...
LILACS

LIS


Full text: Available Collection: International databases Database: MEDLINE Main subject: Virus Diseases / Aging Type of study: Observational study / Prognostic study Limits: Animals / Humans Language: English Journal: J Allergy Clin Immunol Pract Year: 2021 Document Type: Article Affiliation country: J.jaip.2020.11.016