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Longitudinal analysis of antibody response following SARS-CoV-2 infection in pregnancy: From the first trimester to delivery.
Cosma, Stefano; Carosso, Andrea Roberto; Corcione, Silvia; Cusato, Jessica; Borella, Fulvio; Antonucci, Miriam; Marozio, Luca; Revelli, Alberto; Preti, Mario; Ghisetti, Valeria; Di Perri, Giovanni; Benedetto, Chiara.
  • Cosma S; Gynecology and Obstetrics 1, Department of Surgical Sciences, City of Health and Science, University of Turin, Turin, Italy.
  • Carosso AR; Gynecology and Obstetrics 1, Department of Surgical Sciences, City of Health and Science, University of Turin, Turin, Italy. Electronic address: andrea88.carosso@gmail.com.
  • Corcione S; Infectious Diseases, Department of Medical Sciences, University of Turin, Turin, Italy; Tufts University School of Medicine, Boston, MA, USA.
  • Cusato J; Laboratory of Clinical Pharmacology and Pharmacogenetics, Amedeo di Savoia Hospital, Department of Medical Sciences, University of Turin, Turin, Italy.
  • Borella F; Gynecology and Obstetrics 1, Department of Surgical Sciences, City of Health and Science, University of Turin, Turin, Italy.
  • Antonucci M; Laboratory of Clinical Pharmacology and Pharmacogenetics, Amedeo di Savoia Hospital, Department of Medical Sciences, University of Turin, Turin, Italy.
  • Marozio L; Gynecology and Obstetrics 1, Department of Surgical Sciences, City of Health and Science, University of Turin, Turin, Italy.
  • Revelli A; Gynecology and Obstetrics 1, Department of Surgical Sciences, City of Health and Science, University of Turin, Turin, Italy.
  • Preti M; Gynecology and Obstetrics 1, Department of Surgical Sciences, City of Health and Science, University of Turin, Turin, Italy.
  • Ghisetti V; Laboratory of Microbiology and Virology, Amedeo di Savoia Hospital, ASL 'Città di Torino', Turin, Italy.
  • Di Perri G; Unit of Infectious Diseases, Amedeo di Savoia Hospital, Department of Medical Sciences, University of Turin, Turin, Italy.
  • Benedetto C; Gynecology and Obstetrics 1, Department of Surgical Sciences, City of Health and Science, University of Turin, Turin, Italy.
J Reprod Immunol ; 144: 103285, 2021 04.
Article in English | MEDLINE | ID: covidwho-1062496
ABSTRACT
We report herein the longest-lasting study of SARS-CoV-2 antibody profile in pregnancy, from first trimester-infection to delivery. Seventeen out of 164 pregnant women tested positive for COVID-19. Throughout pregnancy, the neutralizing antibody titer remained stable, whilst a significant decline in the non-neutralizing antibodies was observed after 16 weeks of gestation. All the newborns of women who developed IgG antibodies showed the presence of the same antibodies in arterial cord blood. Knowledge on the longevity and type of SARS-CoV-2 antibody response may help to guide vaccination strategies in pregnancy.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pregnancy Complications, Infectious / Immunoglobulin G / Antibodies, Neutralizing / SARS-CoV-2 / COVID-19 / Antibodies, Viral Type of study: Cohort study / Observational study / Prognostic study / Qualitative research Topics: Vaccines Limits: Adult / Female / Humans / Pregnancy Language: English Journal: J Reprod Immunol Year: 2021 Document Type: Article Affiliation country: J.jri.2021.103285

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pregnancy Complications, Infectious / Immunoglobulin G / Antibodies, Neutralizing / SARS-CoV-2 / COVID-19 / Antibodies, Viral Type of study: Cohort study / Observational study / Prognostic study / Qualitative research Topics: Vaccines Limits: Adult / Female / Humans / Pregnancy Language: English Journal: J Reprod Immunol Year: 2021 Document Type: Article Affiliation country: J.jri.2021.103285