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Myeloid cell dynamics correlating with clinical outcomes of severe COVID-19 in Japan.
Takano, Tomohiro; Matsumura, Takayuki; Adachi, Yu; Terahara, Kazutaka; Moriyama, Saya; Onodera, Taishi; Nishiyama, Ayae; Kawana-Tachikawa, Ai; Miki, Shoji; Hosoya-Nakayama, Kaori; Nakamura-Hoshi, Midori; Seki, Sayuri; Tachikawa, Natsuo; Yoshimura, Yukihiro; Miyata, Nobuyuki; Horiuchi, Hiroshi; Sasaki, Hiroaki; Miyazaki, Kazuhito; Kinoshita, Noriko; Sudo, Tsutomu; Akiyama, Yutaro; Sato, Rubuna; Suzuki, Tadaki; Matano, Tetsuro; Takahashi, Yoshimasa.
  • Takano T; Department of Immunology, National Institute of Infectious Diseases, 1-23-1 Toyama, Shinjuku-ku, Tokyo, Japan.
  • Matsumura T; Department of Immunology, National Institute of Infectious Diseases, 1-23-1 Toyama, Shinjuku-ku, Tokyo, Japan.
  • Adachi Y; Department of Immunology, National Institute of Infectious Diseases, 1-23-1 Toyama, Shinjuku-ku, Tokyo, Japan.
  • Terahara K; Department of Immunology, National Institute of Infectious Diseases, 1-23-1 Toyama, Shinjuku-ku, Tokyo, Japan.
  • Moriyama S; Department of Immunology, National Institute of Infectious Diseases, 1-23-1 Toyama, Shinjuku-ku, Tokyo, Japan.
  • Onodera T; Department of Immunology, National Institute of Infectious Diseases, 1-23-1 Toyama, Shinjuku-ku, Tokyo, Japan.
  • Nishiyama A; Department of Immunology, National Institute of Infectious Diseases, 1-23-1 Toyama, Shinjuku-ku, Tokyo, Japan.
  • Kawana-Tachikawa A; AIDS Research Center, National Institute of Infectious Diseases, 1-23-1 Toyama, Shinjuku-ku, Tokyo, Japan.
  • Miki S; AIDS Research Center, National Institute of Infectious Diseases, 1-23-1 Toyama, Shinjuku-ku, Tokyo, Japan.
  • Hosoya-Nakayama K; AIDS Research Center, National Institute of Infectious Diseases, 1-23-1 Toyama, Shinjuku-ku, Tokyo, Japan.
  • Nakamura-Hoshi M; AIDS Research Center, National Institute of Infectious Diseases, 1-23-1 Toyama, Shinjuku-ku, Tokyo, Japan.
  • Seki S; AIDS Research Center, National Institute of Infectious Diseases, 1-23-1 Toyama, Shinjuku-ku, Tokyo, Japan.
  • Tachikawa N; Department of Infectious Diseases, Yokohama Municipal Citizen's Hospital, 1-1 Mitsuzawanishimachi, Kanagawa-ku, Yokohama, Kanagawa, Japan.
  • Yoshimura Y; Department of Infectious Diseases, Yokohama Municipal Citizen's Hospital, 1-1 Mitsuzawanishimachi, Kanagawa-ku, Yokohama, Kanagawa, Japan.
  • Miyata N; Department of Infectious Diseases, Yokohama Municipal Citizen's Hospital, 1-1 Mitsuzawanishimachi, Kanagawa-ku, Yokohama, Kanagawa, Japan.
  • Horiuchi H; Department of Infectious Diseases, Yokohama Municipal Citizen's Hospital, 1-1 Mitsuzawanishimachi, Kanagawa-ku, Yokohama, Kanagawa, Japan.
  • Sasaki H; Department of Infectious Diseases, Yokohama Municipal Citizen's Hospital, 1-1 Mitsuzawanishimachi, Kanagawa-ku, Yokohama, Kanagawa, Japan.
  • Miyazaki K; Department of Infectious Diseases, Yokohama Municipal Citizen's Hospital, 1-1 Mitsuzawanishimachi, Kanagawa-ku, Yokohama, Kanagawa, Japan.
  • Kinoshita N; Disease Control and Prevention Center, National Center for Global Health and Medicine, Toyama, Shinjuku-ku, Tokyo, Japan.
  • Sudo T; Disease Control and Prevention Center, National Center for Global Health and Medicine, Toyama, Shinjuku-ku, Tokyo, Japan.
  • Akiyama Y; Disease Control and Prevention Center, National Center for Global Health and Medicine, Toyama, Shinjuku-ku, Tokyo, Japan.
  • Sato R; Disease Control and Prevention Center, National Center for Global Health and Medicine, Toyama, Shinjuku-ku, Tokyo, Japan.
  • Suzuki T; Department of Pathology, National Institute of Infectious Diseases, Toyama, Shinjuku-ku, Tokyo, Japan.
  • Matano T; AIDS Research Center, National Institute of Infectious Diseases, 1-23-1 Toyama, Shinjuku-ku, Tokyo, Japan.
  • Takahashi Y; Department of Immunology, National Institute of Infectious Diseases, 1-23-1 Toyama, Shinjuku-ku, Tokyo, Japan.
Int Immunol ; 33(4): 241-247, 2021 03 31.
Article in English | MEDLINE | ID: covidwho-1066348
ABSTRACT
An expanded myeloid cell compartment is a hallmark of severe coronavirus disease 2019 (COVID-19). However, data regarding myeloid cell expansion have been collected in Europe, where the mortality rate by COVID-19 is greater than those in other regions including Japan. Thus, characteristics of COVID-19-induced myeloid cell subsets remain largely unknown in the regions with low mortality rates. Here, we analyzed cellular dynamics of myeloid-derived suppressor cell (MDSC) subsets and examined whether any of them correlate with disease severity and prognosis, using blood samples from Japanese COVID-19 patients. We observed that polymorphonuclear (PMN)-MDSCs, but not other MDSC subsets, transiently expanded in severe cases but not in mild or moderate cases. Contrary to previous studies in Europe, this subset selectively expanded in survivors of severe cases and subsided before discharge, but such transient expansion was not observed in non-survivors in Japanese cohort. Analysis of plasma cytokine/chemokine levels revealed positive correlation of PMN-MDSC frequencies with IL-8 levels, indicating the involvement of IL-8 on recruitment of PMN-MDSCs to peripheral blood following the onset of severe COVID-19. Our data indicate that transient expansion of the PMN-MDSC subset results in improved clinical outcome. Thus, this myeloid cell subset may be a predictor of prognosis in cases of severe COVID-19 in Japan.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Interleukin-8 / Myeloid-Derived Suppressor Cells / SARS-CoV-2 / COVID-19 / Neutrophils Type of study: Cohort study / Observational study / Prognostic study Limits: Humans Country/Region as subject: Asia Language: English Journal: Int Immunol Journal subject: Allergy and Immunology Year: 2021 Document Type: Article Affiliation country: Intimm

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Interleukin-8 / Myeloid-Derived Suppressor Cells / SARS-CoV-2 / COVID-19 / Neutrophils Type of study: Cohort study / Observational study / Prognostic study Limits: Humans Country/Region as subject: Asia Language: English Journal: Int Immunol Journal subject: Allergy and Immunology Year: 2021 Document Type: Article Affiliation country: Intimm