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A dynamic model of the Coronavirus Disease 2019 outbreak to analyze the effectiveness of control measures.
Yang, Shuhang; Liu, Yu; Chen, Ke; Li, Tong; Huang, Yi; Chen, Xiaolei; Qi, Pengfang; Xu, Yazhi; Yu, Feifei; Yang, Yuling; Chen, Youhua.
  • Yang S; Yau Mathematical Science Center, Tsinghua University.
  • Liu Y; HuaHuiChangTian (Beijing) Information Technology Co., Ltd.
  • Chen K; School of Nursing, Lanzhou University, Lanzhou.
  • Li T; Chengdu University of Information Technology.
  • Huang Y; Department of Medicine, University of Chicago, Chicago, Illinois.
  • Chen X; Ludong University, Yantai.
  • Qi P; Anhui University of Finance and Economics, Hefei.
  • Xu Y; Liaoning University of Technology, Jinzhou.
  • Yu F; Ocean University of China, Qingdao.
  • Yang Y; Jiangsu Key Laboratory of Urban Underground Engineering & Environmental Safety, Southeast University, Nanjing.
  • Chen Y; CAS Key Laboratory of Mountain Ecological Restoration and Bioresource Utilization & Ecological Restoration and Biodiversity Conservation Key Laboratory of Sichuan Province, Chengdu Institute of Biology, Chinese Academy of Sciences, Chengdu, China.
Medicine (Baltimore) ; 100(5): e23925, 2021 Feb 05.
Article in English | MEDLINE | ID: covidwho-1125827
ABSTRACT
ABSTRACT The World Health Organization (WHO) classified the spread of COVID-19 (Coronavirus Disease 2019) as a global pandemic in March. Scholars predict that the pandemic will continue into the coming winter and will become a seasonal epidemic in the following year. Therefore, the identification of effective control measures becomes extremely important. Although many reports have been published since the COVID-19 outbreak, no studies have identified the relative effectiveness of a combination of control measures implemented in Wuhan and other areas in China. To this end, a retrospective analysis by the collection and modeling of an unprecedented number of epidemiology records in China of the early stage of the outbreaks can be valuable.In this study, we developed a new dynamic model to describe the spread of COVID-19 and to quantify the effectiveness of control measures. The transmission rate, daily close contacts, and the average time from onset to isolation were identified as crucial factors in viral spreading. Moreover, the capacity of a local health-care system is identified as a threshold to control an outbreak in its early stage. We took these factors as controlling parameters in our model. The parameters are estimated based on epidemiological reports from national and local Center for Disease Control (CDCs).A retrospective simulation showed the effectiveness of combinations of 4 major control measures implemented in Wuhan hospital isolation, social distancing, self-protection by wearing masks, and extensive medical testing. Further analysis indicated critical intervention conditions and times required to control an outbreak in the early stage. Our simulations showed that South Korea has kept the spread of COVID-19 at a low level through extensive medical testing. Furthermore, a predictive simulation for Italy indicated that Italy would contain the outbreak in late May under strict social distancing.In our general analysis, no single measure could contain a COVID-19 outbreak once a health-care system is overloaded. Extensive medical testing could keep viral spreading at a low level. Wearing masks functions as favorably as social distancing but with much lower socioeconomic costs.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Communicable Disease Control / Outcome Assessment, Health Care / Physical Distancing / N95 Respirators / SARS-CoV-2 / COVID-19 / Hospitalization Type of study: Experimental Studies / Observational study / Prognostic study Limits: Humans Country/Region as subject: Asia Language: English Journal: Medicine (Baltimore) Year: 2021 Document Type: Article

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Communicable Disease Control / Outcome Assessment, Health Care / Physical Distancing / N95 Respirators / SARS-CoV-2 / COVID-19 / Hospitalization Type of study: Experimental Studies / Observational study / Prognostic study Limits: Humans Country/Region as subject: Asia Language: English Journal: Medicine (Baltimore) Year: 2021 Document Type: Article