Three-dimensional chromatin in infectious disease-A role for gene regulation and pathogenicity?
PLoS Pathog
; 17(2): e1009207, 2021 02.
Article
in English
| MEDLINE | ID: covidwho-1063225
ABSTRACT
The recent Coronavirus Disease 2019 pandemic has once again reminded us the importance of understanding infectious diseases. One important but understudied area in infectious disease research is the role of nuclear architecture or the physical arrangement of the genome in the nucleus in controlling gene regulation and pathogenicity. Recent advances in research methods, such as Genome-wide chromosome conformation capture using high-throughput sequencing (Hi-C), have allowed for easier analysis of nuclear architecture and chromosomal reorganization in both the infectious disease agents themselves as well as in their host cells. This review will discuss broadly on what is known about nuclear architecture in infectious disease, with an emphasis on chromosomal reorganization, and briefly discuss what steps are required next in the field.
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Chromatin
/
Cell Nucleus
/
Communicable Diseases
Limits:
Animals
/
Humans
Language:
English
Journal:
PLoS Pathog
Year:
2021
Document Type:
Article
Affiliation country:
Journal.ppat.1009207
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