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Enhancement of Schiff base biological efficacy by metal coordination and introduction of metallic compounds as anticovid candidates: A simple overview
Reviews in Inorganic Chemistry ; 2021.
Article in English | Scopus | ID: covidwho-1063244
ABSTRACT
In the prevailing apocalyptic times of coronavirus disease (COVID-19), the whole scientific community is busy in designing anticovid drug or vaccine. Under such a fascination, Schiff bases or azomethine compounds are continuously interrogated for antimicrobial properties. These compounds represent interesting molecular scaffolds of huge medicinal and industrial relevance. In order to update the current literature support of such facts this article introduces the synthetic chemistry, mechanism of formation of a Schiff base, followed by biological efficacy and finally a suitable discussion on the mechanism of respective bioactivity. In most of the studies revealing the biological evaluation of azomethine functionalized frameworks, fascinated results have been recorded in case of azomethine-metal complexes as compared with the free ligands. Also, the CH=N or C=N form of organic ligands have indicated marvellous results. Therefore, in connection with the biological relevance and microbicidal implications of such metallic compounds, this works reviews the current update of microorganism fighting efficacy of azomethine metal complexes along with the introduction of some metallodrugs as excellent candidates having COVID-19 defending potentiality. © 2021 Walter de Gruyter GmbH, Berlin/Boston 2021.

Full text: Available Collection: Databases of international organizations Database: Scopus Language: English Journal: Reviews in Inorganic Chemistry Year: 2021 Document Type: Article

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Full text: Available Collection: Databases of international organizations Database: Scopus Language: English Journal: Reviews in Inorganic Chemistry Year: 2021 Document Type: Article