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Prevalence and Clinical Characteristics of SARS-CoV-2 Confirmed and Negative Kawasaki Disease Patients During the Pandemic in Spain.
Fernández-Cooke, Elisa; Grasa, Carlos D; Domínguez-Rodríguez, Sara; Barrios Tascón, Ana; Sánchez-Manubens, Judith; Anton, Jordi; Mercader, Beatriz; Villalobos, Enrique; Camacho, Marisol; Navarro Gómez, María Luisa; Oltra Benavent, Manuel; Giralt, Gemma; Bustillo, Matilde; Bello Naranjo, Ana María; Rocandio, Beatriz; Rodríguez-González, Moisés; Núñez Cuadros, Esmeralda; Aracil Santos, Javier; Moreno, David; Calvo, Cristina.
  • Fernández-Cooke E; Pediatric Infectious Diseases Unit, Department of Pediatrics, Hospital Universitario 12 de Octubre, Madrid, Spain.
  • Grasa CD; Pediatric Research and Clinical Trials Unit (UPIC), Instituto de Investigación Sanitaria Hospital 12 de Octubre (imas12), Madrid, Spain.
  • Domínguez-Rodríguez S; Pediatric Infectious Diseases Unit, Department of Pediatrics, Hospital Universitario La Paz, Madrid, Spain.
  • Barrios Tascón A; Pediatric Research and Clinical Trials Unit (UPIC), Instituto de Investigación Sanitaria Hospital 12 de Octubre (imas12), Madrid, Spain.
  • Sánchez-Manubens J; Department of Pediatrics, Hospital Universitario Infanta Sofia, Madrid, Spain.
  • Anton J; Pediatric Rheumatology Department, Hospital Sant Joan de Déu, Universitat Autònoma de Barcelona, Barcelona, Spain.
  • Mercader B; Pediatric Rheumatology Department, Hospital Sant Joan de Déu, Universitat Autònoma de Barcelona, Barcelona, Spain.
  • Villalobos E; Department of Pediatrics, Hospital Clínico Universitario Virgen de la Arrixaca, Murcia, Spain.
  • Camacho M; Department of Pediatrics, Hospital Infantil Universitario Niño Jesús, Madrid, Spain.
  • Navarro Gómez ML; Pediatric Infectious Diseases, Rheumatology and Immunology Unit, Department of Pediatrics, Hospital Virgen del Rocío, Sevilla, Spain.
  • Oltra Benavent M; Department of Pediatrics, Hospital Universitario Gregorio Marañón, Madrid, Spain.
  • Giralt G; Department of Pediatrics, Hospital Universitario y Politécnico La Fe, Valencia, Spain.
  • Bustillo M; Pediatric Cardiology Unit, Department of Pediatrics, Hospital Universitario Vall d'Hebron Barcelona, Barcelona, Spain.
  • Bello Naranjo AM; Pediatric Infectious Disease Unit, Department of Pediatrics, Hospital Universitario Miguel Servet, Zaragoza, Spain.
  • Rocandio B; Department of Pediatrics, Hospital Universitario Materno-Infantil de Las Palmas de Gran Canaria, Canarias, Spain.
  • Rodríguez-González M; Department of Pediatrics, Hospital Universitario de Donostia, Guipuzcoa, Spain.
  • Núñez Cuadros E; Department of Pediatrics, Hospital Universitario Puerta Del Mar de Cádiz, Cádiz, Spain.
  • Aracil Santos J; Department of Pediatrics, Hospital Regional Universitario de Málaga, Málaga, Spain.
  • Moreno D; Pediatric Infectious Diseases Unit, Department of Pediatrics, Hospital Universitario La Paz, Madrid, Spain.
  • Calvo C; Department of Pediatrics, Hospital Regional Universitario de Málaga, Málaga, Spain.
Front Pediatr ; 8: 617039, 2020.
Article in English | MEDLINE | ID: covidwho-1063350
ABSTRACT

Introduction:

COVID-19 has a less severe course in children. In April 2020, some children presented with signs of multisystem inflammation with clinical signs overlapping with Kawasaki disease (KD), most of them requiring admission to the pediatric intensive care unit (PICU). This study aimed to describe the prevalence and clinical characteristics of KD SARS-CoV-2 confirmed and negative patients during the pandemic in Spain. Material and

Methods:

Medical data of KD patients from January 1, 2018 until May 30, 2020 was collected from the KAWA-RACE study group. We compared the KD cases diagnosed during the COVID-19 period (March 1-May 30, 2020) that were either SARS-CoV-2 confirmed (CoV+) or negative (CoV-) to those from the same period during 2018 and 2019 (PreCoV).

Results:

One hundred and twenty-four cases were collected. There was a significant increase in cases and PICU admissions in 2020 (P-trend = 0.001 and 0.0004, respectively). CoV+ patients were significantly older (7.5 vs. 2.5 yr) and mainly non-Caucasian (64 vs. 29%), had incomplete KD presentation (73 vs. 32%), lower leucocyte (9.5 vs. 15.5 × 109) and platelet count (174 vs. 423 × 109/L), higher inflammatory markers (C-Reactive Protein 18.5vs. 10.9 mg/dl) and terminal segment of the natriuretic atrial peptide (4,766 vs. 505 pg/ml), less aneurysm development (3.8 vs. 11.1%), and more myocardial dysfunction (30.8 vs. 1.6%) than PreCoV patients. Respiratory symptoms were not increased during the COVID-19 period.

Conclusion:

The KD CoV+ patients mostly meet pediatric inflammatory multisystem syndrome temporally associated with COVID-19/multisystem inflammatory syndrome in children criteria. Whether this is a novel entity or the same disease on different ends of the spectrum is yet to be clarified.
Keywords

Full text: Available Collection: International databases Database: MEDLINE Type of study: Observational study / Prognostic study Language: English Journal: Front Pediatr Year: 2020 Document Type: Article Affiliation country: Fped.2020.617039

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Full text: Available Collection: International databases Database: MEDLINE Type of study: Observational study / Prognostic study Language: English Journal: Front Pediatr Year: 2020 Document Type: Article Affiliation country: Fped.2020.617039