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Potential immunomodulatory effects of vitamin D in the prevention of severe coronavirus disease 2019: An ally for Latin America (Review).
Turrubiates-Hernández, Francisco Javier; Sánchez-Zuno, Gabriela Athziri; González-Estevez, Guillermo; Hernández-Bello, Jorge; Macedo-Ojeda, Gabriela; Muñoz-Valle, José Francisco.
  • Turrubiates-Hernández FJ; Institute of Research in Biomedical Sciences, University Center of Health Sciences (CUCS), Guadalajara, Jalisco 44340, México.
  • Sánchez-Zuno GA; Institute of Research in Biomedical Sciences, University Center of Health Sciences (CUCS), Guadalajara, Jalisco 44340, México.
  • González-Estevez G; Institute of Research in Biomedical Sciences, University Center of Health Sciences (CUCS), Guadalajara, Jalisco 44340, México.
  • Hernández-Bello J; Institute of Research in Biomedical Sciences, University Center of Health Sciences (CUCS), Guadalajara, Jalisco 44340, México.
  • Macedo-Ojeda G; Institute of Research in Biomedical Sciences, University Center of Health Sciences (CUCS), Guadalajara, Jalisco 44340, México.
  • Muñoz-Valle JF; Institute of Research in Biomedical Sciences, University Center of Health Sciences (CUCS), Guadalajara, Jalisco 44340, México.
Int J Mol Med ; 47(4)2021 04.
Article in English | MEDLINE | ID: covidwho-1063435
Semantic information from SemMedBD (by NLM)
1. ergocalciferol PREVENTS COVID-19
Subject
ergocalciferol
Predicate
PREVENTS
Object
COVID-19
2. Syndrome COEXISTS_WITH Disease
Subject
Syndrome
Predicate
COEXISTS_WITH
Object
Disease
3. Therapeutic procedure TREATS COVID-19
Subject
Therapeutic procedure
Predicate
TREATS
Object
COVID-19
4. adjunctive treatment PREVENTS Complication
Subject
adjunctive treatment
Predicate
PREVENTS
Object
Complication
5. ergocalciferol PREVENTS COVID-19
Subject
ergocalciferol
Predicate
PREVENTS
Object
COVID-19
6. Syndrome COEXISTS_WITH Disease
Subject
Syndrome
Predicate
COEXISTS_WITH
Object
Disease
7. Therapeutic procedure TREATS COVID-19
Subject
Therapeutic procedure
Predicate
TREATS
Object
COVID-19
8. adjunctive treatment PREVENTS Complication
Subject
adjunctive treatment
Predicate
PREVENTS
Object
Complication
ABSTRACT
Currently, the world is under a pandemic of severe acute respiratory syndrome coronavirus 2 (SARS­CoV­2), responsible for coronavirus disease 2019 (COVID­19). This disease is characterized by a respiratory syndrome that can progress to an acute respiratory distress syndrome. To date, limited effective therapies are available for the prevention or treatment of COVID­19; therefore, it is necessary to propose novel treatment options with immunomodulatory effects. Vitamin D serves functions in bone health and has been recently reported to exert protective effects against respiratory infections. Observational studies have demonstrated an association between vitamin D deficiency and a poor prognosis of COVID­19; this is alarming as vitamin D deficiency is a global health problem. In Latin America, the prevalence of vitamin D deficiency is unknown, and currently, this region is in the top 10 according to the number of confirmed COVID­19 cases. Supplementation with vitamin D may be a useful adjunctive treatment for the prevention of COVID­19 complications. The present review provides an overview of the current knowledge of the potential immunomodulatory effects of vitamin D in the prevention of COVID­19 and sets out vitamin D recommendations for the Latin American population.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Respiratory Tract Infections / Vitamin D / Vitamin D Deficiency / COVID-19 / Immunologic Factors Type of study: Experimental Studies / Observational study / Prognostic study Topics: Long Covid / Traditional medicine Limits: Humans Language: English Journal subject: Molecular Biology / Genetics, Medical Year: 2021 Document Type: Article

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Respiratory Tract Infections / Vitamin D / Vitamin D Deficiency / COVID-19 / Immunologic Factors Type of study: Experimental Studies / Observational study / Prognostic study Topics: Long Covid / Traditional medicine Limits: Humans Language: English Journal subject: Molecular Biology / Genetics, Medical Year: 2021 Document Type: Article