Towards elucidating the structure, function, and druggability of coronavirus cis-acting RNA motifs / Zglebiajac zawilosci struktur, funkcji i lekowalnosci cis motywów RNA u koronawirusów.
Postepy Biochem
; 66(4): 323-335, 2020 12 31.
Article
in Polish
| MEDLINE | ID: covidwho-1064254
ABSTRACT
Coronaviruses are the causative agents of mild to severe respiratory and intestinal infections in humans. They are the largest RNA viruses, which genomes and encoded RNAs are known to fold into the highly-order structures that play essential roles in the viral replication and infectivity cycle. The recent outbreaks of new pathogenic coronaviruses steered researchers' attention into the possibility of targeting their RNAs directly with novel RNA-specific drugs and therapeutic strategies. In this manuscript, we highlight the recent biochemical and biophysical methodological advancements that yielded more in-depth insight into the structural and functional composition of coronaviruses cis-acting RNA motifs. We discuss the complexity of these RNA regulatory elements, their intermolecular interactions, post-transcriptional regulation, and their potential as druggable targets. We also indicate the location and function of unstructured and highly-conserved regions in coronaviruses RNA genomes representing viable aims for antisense oligonucleotide or CRISPR-based antiviral strategies.
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Coronavirus
Limits:
Humans
Language:
Polish
Journal:
Postepy Biochem
Year:
2020
Document Type:
Article
Affiliation country:
Pb.2020_362
Similar
MEDLINE
...
LILACS
LIS