Nickel-Catalyzed Asymmetric Synthesis of α-Arylbenzamides.
Angew Chem Int Ed Engl
; 60(3): 1605-1609, 2021 01 18.
Article
in English
| MEDLINE | ID: covidwho-1064320
ABSTRACT
A nickel-catalyzed asymmetric reductive hydroarylation of vinyl amides to produce enantioenriched α-arylbenzamides is reported. The use of a chiral bisimidazoline (BIm) ligand, in combination with diethoxymethylsilane and aryl halides, enables the regioselective introduction of aryl groups to the internal position of the olefin, forging a new stereogenic center α to the N atom. The use of neutral reagents and mild reaction conditions provides simple access to pharmacologically relevant motifs present in anticancer, SARS-CoV PLpro inhibitors, and KCNQ channel openers.
Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Benzamides
/
Nickel
Type of study:
Experimental Studies
/
Randomized controlled trials
Language:
English
Journal:
Angew Chem Int Ed Engl
Year:
2021
Document Type:
Article
Affiliation country:
Anie.202011342
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